Bay Biosciences provides high quality, clinical grade, biopsy tissue samples, FFPE  tissue blocks with matched cryogenically preserved sera (serum), plasma, peripheral blood mononuclear cells (PBMC) biofluid samples from patients diagnosed with mucous membrane pemphigoid (MMP).

Moreover, the serum, plasma and PBMCs are processed from MMP patient’s peripheral whole-blood using customized collection and processing protocols.

Furthermore, biopsy tissue and matched biofluid samples are collected from unique patients diagnosed with mucous membrane pemphigoid (MMP). The samples are provided to a valued pharmaceutical customer for research, diagnostics, discovery and drug development.

Mucous Membrane Pemphigoid (MMP) Overview

Mucous membrane pemphigoid (MMP) constitutes a group of rare chronic autoimmune disorders. Which blistering lesions primarily affect the various mucous membrane of the body.

In particular, the mucous membranes of the mouth and eyes are most often affected. Additionally, certain conditions may also affect the mucous membranes of the nose, throat, genitalia, and anus.

Moreover, the symptoms of MMP vary among affected individuals depending upon the specific site(s) involved.

Consequently, blistering lesions eventually heal, sometimes with scarring. Furthermore, progressive scarring may potentially lead to serious complications affecting the eyes and throat.

In some cases, blistering lesions also form on the skin, especially in the head and neck area. Ultimately, the exact cause of MMP is unknown.

Signs and Symptoms of Mucous Membrane Pemphigoid (MMP)

Mucous membrane pemphigoid (MMP) is characterized by the development of recurring blistering skin lesions affecting the mucous membranes of the body. As a result, these lesions may result in scarring of the affected area. Specifically, symptoms and severity vary from patient to patient depending upon the specific site(s) involved with the disease.

Notably, the mucous membranes lining the mouth and eyes are most commonly affected. For instance, in some cases, the first sign of Mucous membrane pemphigoid is a red and blistered mouth.

The gums, roof of the mouth (palate), and the mucous membrane lining the inner cheek may be affected. Furthermore, blistering lesions may spread to affect the esophagus (tube that carries food from the mouth to the stomach). As well as the larynx (voice box), potentially resulting in difficulty swallowing (dysphagia) and hoarseness in the voice.

Consequently, once these lesions heal, progressive scarring may occur, resulting in serious complications including narrowing (stricture) of the esophagus and the larynx. Moreover, the opening between the vocal cords may also narrow.

In rare severe cases, such symptoms can ultimately result in life-threatening complications such as asphyxiation (suffocation), depriving the patient of oxygen, which can result in unconsciousness or death.

Causes of Mucous Membrane Pemphigoid (MMP)

Initially, the exact cause of mucous membrane pemphigoid (MMP) is unknown. Notably, MMP is an autoimmune disease.

In addition, when the body’s natural defenses (antibodies or immunoglobulins) against “foreign” or invading organisms (antigens) begin to attack healthy tissue for unknown reasons, they cause autoimmune disorders.

Specifically, the term autoantibody is used to describe antibodies that are created to attack healthy tissue.

Additionally, scientists use the term autoantigen (“self” antigen) to describe the normal tissues and cells of the body that autoantibodies target.

In patients who have mucous membrane pemphigoid (MMP), autoantibodies are being produced that attack the basement membrane zone (BMZ) of the epithelium. 

Specifically, people can think of the BMZ as a sort of glue that holds the outer layer of skin onto the underlying tissues. Once autoantibodies attack and destroy this glue, consequently, they no longer tack down the skin, allowing it to lift off and produce blisters.

Moreover, researchers believe that in some cases, affected individuals may have a genetic susceptibility to developing some forms of mucous membrane pemphigoid. In these cases, several factors may contribute to the development of the disorder, including immunological, genetic, environmental, and other factors.

Furthermore, in a small number of patients, mucous membrane pemphigoid (MMP) may be caused by the use of certain prescription drugs. Additionally, skin lesions associated with some cases of MMP may appear following trauma to the affected area. Similarly, some cases of MMP affecting the eyes may become apparent after eye (ocular) surgery, such as cataract removal.

Who gets affected by Mucous Membrane Pemphigoid (MMP)

Mucous membrane pemphigoid affects female patients twice as often as male patients. The MMP disorder can occur at any age. However the average age of onset of MMP in patients is between 60 to 70 years of age. Mucous membrane pemphigoid disease is difficult to identify and correctly diagnose, many researchers believe this disease under-diagnosed. 

Biospecimens

biospecimens

Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Moreover, human biospecimens are available including tumor tissue, serum, plasma and PBMC Samples from most other therapeutic areas.

Furthermore, Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and likewise normal healthy donors for controls. Additionally, available in all formats and types.

In fact, our biobank procures and stores fully consented, de-identified and institutional review boards (IRB) approved human tissue samples, human biofluids such as serum samples, plasma samples from various diseases and matched controls.

Also, all our human tissue collections, human biospecimens and human biofluids are provided with detailed, samples associated patient’s clinical data.

In fact, this critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Additionally, researchers find the patient’s data associated with the human biospecimens extremely valuable and use it to help identify new effective treatments (drug discovery & development) in oncology, as well as in other therapeutic areas and diseases.

Bay Biosciences banks wide variety of human tissue samples and human biological samples, including fresh frozen human biospecimens cryogenically preserved at – 80°C.

For example fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as human serum, human plasma and human PBMCs.

Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) and human bio-fluids from diseased and normal healthy donors which includes:

  • Firstly, peripheral whole-blood
  • Secondly, amniotic fluid
  • Thirdly, bronchoalveolar lavage fluid (BAL)
  • Next, sputum
  • Also, pleural effusion
  • Moreover, cerebrospinal fluid (CSF)
  • Likewise, serum (sera)
  • In addition, plasma
  • Moreover, peripheral blood mononuclear cells (PBMC) 
  • Furthermore, saliva
  • Next, buffy coat
  • Accordingly, urine
  • For example, Stool samples
  • Also, aqueous humor
  • And, vitreous humor
  • Lastly, kidney stones (renal calculi)
  • Finally, other bodily fluids from most diseases including cancer.

Moreover, we can also procure most human biospecimens and human biofluids, special collections and requests for human samples that are difficult to find. All our human tissue samples and human biofluids are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human biofluids such as  human plasma, human serum, and human PBMCs bio-fluid samples using custom processing protocols. you buy donor-specific collections in higher volumes and specified sample aliquots from us in multiple format and sets.

Bay Biosciences also provides human biospecimens from normal healthy donors; volunteers, for controls and clinical research, Contact us Now.