Bay Biosciences provides fresh frozen (-80°), high quality, clinical grade serum (sera) and plasma samples processed from NALFD?NASH patients.

Additionally, the samples are processed from unique patients diagnosed with nonalcoholic fatty liver disease (NAFLD) and Non-Alcoholic Steatohepatitis (NASH).

Moreover, detailed clinical data, including donor’s age, sex, race, corresponding smoking and alcohol use, BMI, and pathology, serology, biomarkers associated with the samples, is provided to a valued pharmaceutical customer for research, discovery, and development.

 

 

Non-Alcoholic Fatty Liver Disease (NAFLD) Overview

Non-alcoholic fatty liver disease (NAFLD) refers to a range of conditions caused by a build-up of fat in the liver. In particular, it is usually seen in individuals who are overweight or obese. **Moreover**, NAFLD has been found by researchers in 40 to 80 percent  of patients with type 2 diabetes and in 30 to 90 percent of individuals who are obese.

Furthermore, the more severe form of NAFLD is known as nonalcoholic steatohepatitis (NASH). In addition, NASH involves liver inflammation and damage resulting from a buildup of fat in the liver. Consequently, it is part of a group of conditions categorized as nonalcoholic fatty liver disease (NAFLD).

Non-Alcoholic Steatohepatitis (NASH)

Notably, one of the leading causes of cirrhosis in adults in the United States is non-alcoholic steatohepatitis (NASH). Specifically, cirrhosis may affect up to 25% of adults with NASH.

Although the condition can worsen and lead to liver scarring, which results in cirrhosis, it does not always progress. Interestingly, the type of liver disease associated with NASH resembles that caused by long-term, heavy drinking, but it occurs in individuals who do not abuse alcohol.

As a result, the cardio-metabolic condition of patients worsens due to NASH, which is also linked to a higher risk of death from cardiovascular events.

Signs and Symptoms of Non-Alcoholic Steatohepatitis (NASH)

Most patients with NASH and other forms of NAFLD have no symptoms. Those who do develop symptoms may feel tired or have pain in the upper right side of the abdomen.

Children with NASH may experience:

  • Fatigue
  • Pain in the middle or upper-right part of the abdomen
  • Patches of darker, discolored skin, usually on the neck or under the arms

A doctor may only diagnose NASH after many years, when cirrhosis occurs. Anyone who develops any of the following symptoms should contact a doctor:

  • A swollen belly
  • Behavioral changes such as slurred speech or confusion
  • Easy bruising and bleeding
  • Intense itchiness
  • Spider veins just under the skin
  • Yellowing of the whites of the eyes, and in some people, the skin

Receiving appropriate care is key. If a person with NASH develops cirrhosis, this increases the risk of developing hepatocellular carcinoma, a common type of liver cancer.

Causes of Non-Alcoholic Steatohepatitis (NASH)

While the cause of NASH is unclear, ongoing research suggests that the following may play a role:

  • Apoptosis, or programmed cell death, of liver cells
  • Intestinal bacteria, which may cause inflammation of the liver
  • Oxidative stress, an imbalance between the production of free radicals and antioxidants
  • Patient’s genetic makeup
  • Overproduction and release of cytokines, types of toxic inflammatory protein that the body produces

Treatment Non-Alcoholic Steatohepatitis (NASH)

There are no specific medical treatments for NASH. Taking the following steps can help prevent further damage:

  • Controlling blood cholesterol levels
  • Maintaining a moderate weight, and if this involves losing weight, doing so gradually
  • Getting regular exercise
  • Having a balanced, healthy diet with low amounts of processed foods and fats, and little, if any, fructose
  • Limiting or avoiding alcohol
  • Managing diabetes, for anyone who has it

If a person with NASH also has cirrhosis, the treatment may include medications and possibly surgery.

Patients with NASH who develop liver cancer or liver failure may require a transplant.

Biospecimens

biospecimens

Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Human biospecimens are available including cancer (tumor) tissue, cancer serum, cancer plasma, cancer peripheral blood mononuclear cells (PBMC). and human tissue samples from most other therapeutic areas and diseases.

Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors for controls, available in all formats and types.

In fact, our biobank procures and stores fully consented, de-identified and institutional review boards (IRB) approved human tissue samples, human biofluids such as serum samples, plasma samples from various diseases and matched controls.

Also, all our human tissue collections, human biospecimens and human biofluids are provided with detailed, samples associated patient’s clinical data.

In fact, this critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Additionally, researchers find the patient’s data associated with the human biospecimens extremely valuable and use it to help identify new effective treatments (drug discovery & development) in oncology, as well as in other therapeutic areas and diseases.

Bay Biosciences banks wide variety of human tissue samples and human biological samples, including fresh frozen human biospecimens cryogenically preserved at – 80°C.

For example fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as human serum, human plasma and human PBMCs.

Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) and human biofluids from diseased and normal healthy donors which includes:

Moreover, we can also procure most human biospecimens and human biofluids, special collections and requests for human samples that are difficult to find. All our human tissue samples and human biofluids are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human biofluids such as  human plasma, human serum, and human PBMCs bio-fluid samples using custom processing protocols; you buy donor-specific collections in higher volumes and specified sample aliquots from us.

Bay Biosciences also provides human biospecimens from normal healthy donors; volunteers, for controls and clinical research, Contact us Now.