Bay Biosciences provides high quality, clinical grade, biopsy tissue samples, FFPE tissue blocks with matched cryogenically preserved sera (serum), plasma, peripheral blood mononuclear cells (PBMC) biofluid samples from patients diagnosed with neuroendocrine prostate cancer (NEPC).
The sera (serum), plasma and PBMC biofluid specimens are processed from neuroendocrine prostate cancer (NEPC) patient’s peripheral whole-blood using customized collection and processing protocols.
Biopsy tissue and matched biofluid samples are collected from unique patients diagnosed with neuroendocrine prostate cancer (NEPC) and are provided to a valued pharmaceutical customer for research, diagnostics, discovery and drug development.
Detailed clinical data, patient’s history, complete blood count (CBC), serology, MRI, biopsy tissue findings, histopathology information, elevated biomarker levels, genetic and metabolic information associated with neuroendocrine prostate cancer (NEPC) specimens is provided to a valued customer for research, development and drug discovery.
The neuroendocrine prostate cancer (NEPC), sera (serum), plasma and peripheral blood mononuclear cells (PBMC) biofluids are processed from patients peripheral whole-blood using customized collection and processing protocols.
Neuroendocrine Prostate Cancer (NEPC) Overview
Neuroendocrine prostate cancer (NEPC) is an aggressive variant of prostate cancer that may arise from the start in patients previously treated with hormonal therapies for prostate adenocarcinoma as a mechanism of resistance.
The prostate is a small gland about the size of a walnut that sits between the bladder and the penis, just in front of the rectum. The urethra which is the tube through which urine is passed runs through the prostate.
The prostate produces seminal fluid, that helps to feed and protect sperm. During ejaculation the prostate secretes this fluid into the urethra, where it mixes with sperm and is expelled through the penis as semen.
NECP cancers are rare, less than 2% of all prostate cancers are NECP and is usually associated with aggressive disease, more likely to be neuroendocrine carcinoma than neuroendocrine tumor.
It is difficult to accurately diagnose and distinguish it from prostate cancer, without pathology investigation and expert review of cells under a microscope. Approximately 1% of all of the cells within the prostate gland are neuroendocrine in origin.
Therefore it is not unusual to see some neuroendocrine presence in a prostate cancer sample. It is, therefore, vital is to establish not only the number of neuroendocrine cells within the sample (and whether they are abnormal i.e. cancerous) but also how many there are in comparison to prostate cancer cells.
Neuroendocrine Prostate Cancer (NEPC) may arise de novo (that is without a previous history of prostate cancer) or develop in the later stages of castration-resistant prostate cancer following previous hormone or taxane-based therapy treatment emergent Neuroendocrine Prostate Cancer (t-NEPC).
NEPC and t-NEPC are less likely to express prostate-specific antigen (PSA), however PSA test may be useful in helping diagnosis and directing treatment.
Causes of Neuroendocrine Prostate Cancer (NEPC)
Exact causes of developing neuroendocrine cancer are unknown, however it is important to follow advice in leading a healthy lifestyle: eat healthily, exercise and avoid smoking and drinking too much alcohol.
Most Neuroendocrine Cancers do not run in families, however, a number of rare conditions may increase the risk of developing NECP. Therefore, if other members of the family have been diagnosed with cancer, or have a known genetic condition.
Signs and Symptoms of Neuroendocrine Prostate Cancer (NEPC)
Signs and symptoms, if they occur, maybe similar to those experienced by someone with an enlarged prostate, a bladder infection and/or suspected prostate cancer:
- Urge to urinate frequently at night specially during night time
- Weak or interrupted urine flow or the need to strain to empty the bladder
- Erectile dysfunction
- Pain and discomfort when sitting, usually casued by enlarged prostate gland
- Blood in the urine (hematuria)
- Blood in the seminal fluid
- Pain or burning sensation during urination.
Following are other, possible signs and symptoms of late stage NECP cancer::
- Fatigue
- Pain in the back, hips, thighs, shoulders, or other bones
- Swelling or fluid buildup in the legs or feet
- Unexplained weight loss
- Change in bowel movements
Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens and human bio-fluid collections.
Samples available are cancer (tumor) tissue, cancer serum, cancer plasma cancer PBMC and human tissue samples from most other therapeutic areas and diseases.
Bay Biosciences maintains and manages its own bio-repository, human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors available in all formats and types.
Our biobank procures and stores fully consented, deidentified and institutional review boards (IRB) approved human tissue samples and matched controls.
All our human tissue collections, human specimens and human bio-fluids are provided with detailed samples associated patient’s clinical data.
This critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers and genetic information.
Patient’s data is extremely valuable for researchers and is used to help identify new effective treatments (drug discovery & development) in oncology, other therapeutic areas and diseases.
This clinical information is critical to demonstrate their impact, monitor the safety of medicines, testing & diagnostics, and generate new knowledge about the causes of disease and illness.
Bay Biosciences banks wide variety of human tissue samples and biological samples including cryogenically preserved at – 80°C.
Including fresh frozen tissue samples, tumor tissue samples, FFPE’s, tissue slides, with matching human bio-fluids, whole blood and blood derived products such as serum, plasma and PBMC’s.
Bay Biosciences is a global leader in collecting and providing human tissue samples according to the researchers specified requirements and customized, tailor-made collection protocols.
Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.
Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors which includes:
- Peripheral whole-blood,
- Amniotic fluid
- Bronchoalveolar lavage fluid (BAL)
- Sputum
- Pleural effusion
- Cerebrospinal fluid (CSF)
- Serum (sera)
- Plasma
- Peripheral blood mononuclear cells (PBMC’s)
- Saliva
- Buffy coat
- Urine
- Stool samples
- Aqueous humor
- Vitreous humor
- Kidney stones (renal calculi)
- Other bodily fluids from most diseases including cancer.
We can also procure most human bio-specimens and can-do special collections and requests of human samples that are difficult to find. All our human tissue samples are procured through IRB approved clinical protocols and procedures.
In addition to the standard processing protocols Bay Biosciences can also provide human plasma, serum, PBMC bio-fluid samples using custom processing protocols, you can buy donor specific sample collections in higher volumes and specified sample aliquoting from us.
Bay Biosciences also provides human samples from normal healthy donors, volunteers, for controls and clinical research, contact us Now.
日本のお客様は、ベイバイオサイエンスジャパンBay Biosciences Japanまたはhttp://baybiosciences-jp.com/contact/までご連絡ください。