Bay Biosciences provides Osteosarcoma tumor tissue samples FFPE blocks from unique pediatric patients. Detailed clinical data and pathology annotations including patient’s corresponding diagnostic test values associated with the Osteosarcoma tumor tissue samples FFPE blocks are provided to a valued pharmaceutical customer for In-vitro research and drug discovery.
Osteosarcoma Overview
Osteosarcoma (also called osteogenic sarcoma) is the most common type of cancer that starts in the bones, it is usually found at the end of long bones, often around the knee, but can occur anywhere in the body. Other sites for osteosarcoma include the upper leg, or thighbone, the lower leg, upper arm bone, or any bone in the body, including those in the pelvis, shoulder, and skull.
Osteosarcoma is a type of bone cancer that usually develops in the osteoblast cells that form bone. The cancer cells in these tumors look like early forms of bone cells that normally help make new bone tissue, but the bone tissue in an osteosarcoma is not as strong as that of normal bones. Most patients diagnosed with osteosarcoma are under the age of 25, and it is thought to occur more often in males than females. Osteosarcoma accounts for about 3% of cancers that happen in children
Approximately 800 new cases of osteosarcoma are reported each year in the United States. Most osteosarcomas occur in children and young adults. Teens are the most commonly affected age group, but osteosarcoma can develop at any age. Boys are more likely to have osteosarcoma than girls, and most cases of osteosarcoma involve the knee.
Causes of Osteosarcoma
The exact causes of osteosarcoma is unknown, but it is believed to be due to DNA mutations inside bone cells, either inherited or acquired after birth.
Risk Factors of Osteosarcoma
Osteosarcoma is most often seen in teenage boys. Teens diagnosed with osteosarcoma tend to be tall for their age, suggesting that rapid bone growth may lead to the disease. Kids who have inherited one of the rare cancer syndromes also are at higher risk for osteosarcoma. Following are the risk factors of Osteosarcoma:
- Teenage growth spurts
- Being tall for a specific age
- Previous treatment with radiation for another cancer, especially at a young age or with high doses of radiation
- Presence of certain benign (noncancerous) bone diseases
Presence of certain rare, inherited disorders, such as the following:
- Li-Fraumeni syndrome: A rare family predisposition to multiple types of cancers (such as soft tissue sarcomas, breast cancer, brain tumors, osteosarcoma, and others) caused by a mutation in a gene, the p53 tumor-suppressor gene that normally suppress cancer.
- Rothmund Thompson syndrome: A rare inherited syndrome that includes skeletal problems, rashes, short stature, and an increased risk of developing osteosarcoma. It is caused by an abnormality in the REQL4 gene.
- Hereditary retinoblastoma. A cancer of the eye that usually happens in children younger than 4 years old.
Signs and Symptoms of Osteosarcoma
Each individual Osteosarcoma patient may experience symptoms differently. Following are the most common symptoms of Osteosarcoma:
- Pain in the affected bone
- Swelling around the affected area
- Increased pain with activity or lifting
- Limping
- Decreased movement of the affected limb
Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens and human bio-fluid collections from cancer (tumor) tissue, cancer serum, cancer plasma cancer PBMC and human tissue samples from most other therapeutic areas and diseases.
Bay Biosciences maintains and manages it’s own bio-repository, human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors available in all formats and types. Our biobank procures and stores fully consented, deidentified and institutional review boards (IRB) approved human tissue samples and matched controls.
All our human human tissue collections, human specimens and human bio-fluids are provided with detailed samples associated patient’s clinical data. This critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers and genetic information. Patient’s data is extremely valuable for researchers and is used to help identify new effective treatments (drug discovery & development) in oncology, other therapeutic areas and diseases. This clinical information is critical to demonstrate their impact, monitor the safety of medicines, testing & diagnostics, and generate new knowledge about the causes of disease and illness.
Bay Biosciences banks wide variety of human tissue samples and biological samples including cryogenically preserved -80°C, fresh, fresh frozen tissue samples, tumor tissue samples, FFPE’s, tissue slides, with matching human bio-fluids, whole blood and blood derived products such as serum, plasma and PBMC’s.
Bay Biosciences is a global leader in collecting and providing human tissue samples according to the researchers specified requirements and customized, tailor made collection protocols. Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.
Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors; including peripheral whole-blood, amniotic fluid, bronchoalveolar lavage fluid (BAL), sputum, pleural effusion, cerebrospinal fluid (CSF), serum (sera), plasma, peripheral blood mononuclear cells (PBMC’s), saliva, Buffy coat, urine, stool samples, aqueous humor, vitreous humor, kidney stones, renal calculi, nephrolithiasis, urolithiasis and other bodily fluids from most diseases including cancer. We can also procure most human bio-specimens and can do special collections and requests of human samples that are difficult to find. All our human tissue samples are procured through IRB approved clinical protocols and procedures.
In addition to the standard processing protocols Bay Biosciences can also provide human plasma, serum, PBMC bio-fluid samples using custom processing protocols, you can buy donor specific sample collections in higher volumes and specified sample aliquoting from us. Bay Biosciences also provides human samples from normal healthy donors, volunteers, for controls and clinical research, contact us Now.
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