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Retina

The retina is the layer of cells lining the back wall inside the eye. This layer senses light and sends signals to the brain so you can see. 

The retina is the sensory membrane that lines the inner surface of the back of the eyeball. It’s composed of several layers, including one that contains specialized cells called photoreceptors. There are two types of photoreceptor cells in the human eye, which are called rods and cones. Rod photoreceptors detect motion, provide black-and-white vision and function well in low light. Cones are responsible for central vision and colored vision and perform best in medium and bright light.

Rods are located throughout the retina; cones are concentrated in a small central area of the retina called the macula. At the center of the macula is a small depression known as the fovea. The fovea contains only cone photoreceptors and is the point in the retina responsible for maximum visual acuity and color vision.

Function of the Retina

Photoreceptors cells take light focused by the cornea and lens and convert it into chemical and nervous signals which are transported to visual centers in the brain by way of the optic nerve. In the visual cortex of the brain, which is located in the back of the brain, these signals are converted into images and visual perceptions.

Problems of the Retina

There is a wide variety of retina problems, conditions and diseases. Here is a short list of the more common retina problems:

Macular Degeneration: Age-related macular degeneration (AMD) is the most common serious, age-related eye disease, affecting 9.1 million Americans. And the prevalence of AMD, which affects one in 14 Americans over age 40 and more than 30 percent of seniors over age 75. As the U.S. population continues to age. According to statistics, one-third of males and one-quarter of females over 75 have some form of AMD.

Diabetic Retinopathy: One of the devastating consequences of diabetes is damage to the blood vessels that supply and nourish the retina, leading to significant vision loss.

Macular Edema: This is an accumulation of fluid and swelling of the macula, causing distortion and blurred central vision. Macular edema has several causes, including diabetes. In some cases, swelling of the macula can occur after cataract surgery.

Central Serous Retinopathy: This is when fluid builds up under the central retina, causing distorted vision. Though the cause of central serous retinopathy (CSR) often is unknown, it tends to affect men in their 30s to 50s more frequently than women, and stress appears to be a major risk factor.

Hypertensive Retinopathy: Chronic high blood pressure can damage the tiny blood vessels that nourish the retina, leading to significant vision problems. Risk factors for hypertensive retinopathy are the same as those for high blood pressure, including obesity, lack of physical activity, eating too much salt, a family history of hypertension and a stressful lifestyle.

Solar Retinopathy: This is damage to the macula from staring at the sun, which can cause a permanent blind spot (scotoma) in your visual field. The risk of solar retinopathy which is also known as solar maculopathy, is greatest when viewing a solar eclipse without adequate eye protection.

Detached Retina: A retinal detachment or a pulling away of the retina from the underlying choroid layer of the eye that provides its nourishment, is a medical emergency. If the retina is not surgically reattached as soon as possible, permanent and worsening vision loss can occur.

Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens and human bio-fluid collections from cancer (tumor) tissue, cancer serum, cancer plasma cancer PBMC and human tissue samples from most other therapeutic areas and diseases.

Bay Biosciences maintains and manages it’s own bio-repository, human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors available in all formats and types. Our biobank procures and stores fully consented, deidentified and institutional review boards (IRB) approved human tissue samples and matched controls.

All our human human tissue collections, human specimens and human bio-fluids are provided with detailed samples associated patient’s clinical data. This critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers and genetic information. Patient’s data is extremely valuable for researchers and is used to help identify new effective treatments (drug discovery & development) in oncology, other therapeutic areas and diseases. This clinical information is critical to demonstrate their impact, monitor the safety of medicines, testing & diagnostics, and generate new knowledge about the causes of disease and illness. 

Bay Biosciences banks wide variety of human tissue samples and biological samples including cryogenically preserved -80°C, fresh, fresh frozen tissue samplestumor tissue samples, FFPE’s, tissue slides, with matching human bio-fluids, whole blood and blood derived products such as serumplasma and PBMC’s.

Bay Biosciences is a global leader in collecting and providing human tissue samples according to the researchers specified requirements and customized, tailor made collection protocols. Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors; including peripheral whole-blood, amniotic fluid, bronchoalveolar lavage fluid (BAL), sputum, pleural effusion, cerebrospinal fluid (CSF), serum (sera), plasma, peripheral blood mononuclear cells (PBMC’s), saliva, Buffy coat, urine, stool samples, aqueous humor, vitreous humor, kidney stones, renal calculi, nephrolithiasis, urolithiasis and other bodily fluids from most diseases including cancer. We can also procure most human bio-specimens and can do special collections and requests of human samples that are difficult to find. All our human tissue samples are procured through IRB approved clinical protocols and procedures. 

In addition to the standard processing protocols Bay Biosciences can also provide human plasmaserum, PBMC bio-fluid samples using custom processing protocols, you can buy donor specific sample collections in higher volumes and specified sample aliquoting from us. Bay Biosciences also provides human samples from normal healthy donors, volunteers, for controls and clinical research, contact us Now.

 

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