Bay Biosciences provides high quality, clinical grade, biopsy tissue samples, FFPE tissue blocks with matched cryogenically preserved sera (serum), plasma, peripheral blood mononuclear cells (PBMC) biofluid samples from patients diagnosed with Sjogren’s Syndrome.
The sera (serum), plasma and PBMC biofluid specimens are processed from Sjogren’s syndrome patient’s peripheral whole-blood using customized collection and processing protocols.
Biopsy tissue and matched biofluid samples are collected from unique patients diagnosed with Sjogren’s syndrome and are provided to a valued pharmaceutical customer for research, diagnostics, discovery and drug development.
Detailed clinical data, patient’s history, symptoms, complete blood count (CBC), serology, MRI, biopsy tissue findings, histopathology information, elevated biomarker levels, genetic and metabolic information associated with Sjogren’s syndrome specimens is provided to a valued customer for research, development and drug discovery.
The Sjogren’s syndrome, sera (serum), plasma and peripheral blood mononuclear cells (PBMC) biofluids are processed from patients peripheral whole-blood using customized collection and processing protocols.
Sjogren’s Syndrome Overview
Sjogren’s syndrome (SS) is a systemic, long-term autoimmune disease that affects the body’s moisture-producing (lacrimal and salivary) glands and often seriously affects other organs systems, such as the lungs, kidneys, and nervous system. Sjogren’s syndrome is identified by its two most common symptoms, dry eyes and a dry mouth.
The condition often accompanies other immune system disorders, such as rheumatoid arthritis and Systemic Lupus Erythematosus (SLE). About half of the time Sjogren’s syndrome occurs alone, and the other half it occurs in the presence of another autoimmune connective tissue disease.
In Sjogren’s syndrome, the mucous membranes and moisture-secreting glands of the eyes and mouth are usually affected first, resulting in decreased tears and saliva.
Although Sjogren’s syndrome can develop in patients at any age, most patients affected are older than 40 years at the time of diagnosis.
The condition is much more common in older women. Treatment focuses on relieving symptoms. As a systemic disease, affecting the entire body, symptoms may remain steady or worsen overtime.
According to the Sjogren’s foundation it is estimated that there are four million Americans living with this disease, making it one of the most prevalent autoimmune diseases in the Unites States.
Causes of Sjogren’s Syndrome
Exact causes of Sjogren’s syndrome are unknown, but it is an autoimmune diseases. Patients with Sjogren’s syndrome have abnormal proteins in their blood. This suggests that the immune system, which normally functions to protect the body against cancers and infections, is reacting against its own tissue.
The decrease in tears and saliva seen in Sjogren’s syndrome occurs when the glands that produce these fluids are damaged by inflammation. Research suggests that genetic factors and possibly viral infections may predispose people to developing Sjogren’s syndrome.
Signs and Symptoms of Sjogren’s Syndrome
Dry mouth is a common symptom of Sjogren’s syndrome, which can increase the risk of cavities. It can also make it more difficult to speak or swallow.
Chewing gum or sucking on candies may help with this symptom. In Sjogren’s syndrome dryness of the eyes often occur, too. This may feel like a burning sensation or like something is in your eye.
Sjogren’s syndrome can affect the whole body. Some individuals have vaginal dryness, dry skin, fatigue, rashes, or joint pain. Sjogren’s syndrome can cause inflammation of organs like the kidneys or lungs.
Sjogren’s syndrome patients may have constant inflammation, your doctor might prescribe medications to help prevent organ damage. These medications are called disease-modifying anti-rheumatic drugs. They help tamp down the immune system even more than immune-suppressing drugs.
Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens and human bio-fluid collections.
We have samples available are cancer (tumor) tissue, cancer serum, cancer plasma cancer PBMC and human tissue samples from most other therapeutic areas and diseases.
Our company Bay Biosciences maintains and manages its own bio-repository, human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors available in all formats and types.
Our biobank procures and stores fully consented, deidentified and institutional review boards (IRB) approved human tissue samples and matched controls.
All our human tissue collections, human specimens and human bio-fluids are provided with detailed samples associated patient’s clinical data.
This critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers and genetic information.
Patient’s data is extremely valuable for researchers and is used to help identify new effective treatments (drug discovery & development) in oncology, other therapeutic areas and diseases.
This clinical information is critical to demonstrate their impact, monitor the safety of medicines, testing & diagnostics, and generate new knowledge about the causes of disease and illness.
Bay Biosciences banks wide variety of human tissue samples and biological samples including cryogenically preserved at – 80°C.
Including fresh frozen tissue samples, tumor tissue samples, FFPE’s, tissue slides, with matching human bio-fluids, whole blood and blood derived products such as serum, plasma and PBMC’s.
Bay Biosciences is a global leader in collecting and providing human tissue samples according to the researchers specified requirements and customized, tailor-made collection protocols.
Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.
Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors which includes:
- Peripheral whole-blood,
- Amniotic fluid
- Bronchoalveolar lavage fluid (BAL)
- Sputum
- Pleural effusion
- Cerebrospinal fluid (CSF)
- Serum (sera)
- Plasma
- Peripheral blood mononuclear cells (PBMC’s)
- Saliva
- Buffy coat
- Urine
- Stool samples
- Aqueous humor
- Vitreous humor
- Kidney stones (renal calculi)
- Other bodily fluids from most diseases including cancer.
We can also procure most human bio-specimens and can-do special collections and requests of human samples that are difficult to find. All our human tissue samples are procured through IRB approved clinical protocols and procedures.
In addition to the standard processing protocols Bay Biosciences can also provide human plasma, serum, PBMC bio-fluid samples using custom processing protocols, you can buy donor specific sample collections in higher volumes and specified sample aliquots from us.
Bay Biosciences also provides human samples from normal healthy donors, volunteers, for controls and clinical research, contact us Now.
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