Bay Biosciences provides high quality clinical grade fresh frozen serum, plasma, peripheral blood mononuclear cells (PBMC) biofluid samples derived from whole blood from unique patients diagnosed with Ulcerative colitis, Inflammatory Bowel Disease (IBD).
Ulcerative Colitis is an inflammatory bowel disease (IBD) that causes long-lasting inflammation and ulcers (sores) in the human digestive tract. Inflammatory Bowel Disease (IBD) encompasses several conditions, including Crohn’s disease, Ulcerative Colitis, and indeterminate colitis. According to the CDC It is estimated 1.3% of US adults (3 million) reported being diagnosed with IBD (either Crohn’s disease or ulcerative colitis. Ulcerative colitis has an incidence of 9 to 20 cases per 100,000 persons per year. Its prevalence is 156 to 291 cases per 100,000 persons per year.
Ulcerative colitis affects the innermost lining of the large intestine (colon) and rectum, which results in diffuse friability and superficial erosions on the colonic wall associated with bleeding. It is the most common form of inflammatory bowel disease worldwide. Symptoms usually develop over time. Ulcerative colitis can be debilitating and can sometimes lead to life-threatening complications. Most patients with Ulcerative Colitis have mild to moderate symptoms, while it has no known cure, treatment can greatly reduce signs and symptoms of the disease and even bring about long-term remission.
Types of Ulcerative Colitis
Ulcerative Colitis is usually classified according to the location where the disease occurs. Following are the types of ulcerative colitis disease:
- Ulcerative Proctitis: Inflammation and pain is confined to the area closest to the anus (rectum), and rectal bleeding may be the only sign of the disease.
- Proctosigmoiditis. Inflammation involves the rectum and sigmoid colon, which is the lower end of the colon. Signs and symptoms include bloody diarrhea, abdominal cramps and pain, and an inability to move the bowels in spite of the urge to do so (tenesmus).
- Left-sided colitis: Inflammation extends from the rectum up through the sigmoid and descending colon. Signs and symptoms include bloody diarrhea, abdominal cramping and pain on the left side, and urgency to defecate.
- Pancolitis: This type often affects the entire colon and causes bouts of bloody diarrhea that may be severe, abdominal cramps and pain, fatigue, and significant weight loss due to malnutrition.
Signs and Symptoms of Ulcerative Colitis
Ulcerative colitis symptoms can vary, depending on the severity of inflammation and where it occurs. Most of the ulcerative colitis patients have mild to moderate symptoms. The course of ulcerative colitis disease may vary, with some people having long periods of remission and signs and symptoms not returning for a while.
Following are the common signs and symptoms of Ulcerative Colitis:
- Diarrhea, with blood or pus
- Abdominal pain and cramping
- increased abdominal sounds
- Rectal pain
- Rectal bleeding — passing small amount of blood with stool
- Urgency to defecate
- Inability to defecate despite feeling the urgency (tenesmus)
- Weight loss
- Malnutrition
- Fatigue
- Fever
Ulcerative Colitis can also cause the following additional conditions:
Causes of Ulcerative Colitis
The exact cause of ulcerative colitis are unknown. Researchers believe that Inflammatory Bowel Diseases including Ulcerative Colitis stems from a complex interaction between genetics, the bacterial composition of the digestive tract, environmental factors, and the immune system.
Ulcerative Colitis may be the result of an overactive immune system. However, it’s unclear why some immune systems respond by attacking the large intestines and not others. One possible cause is an immune system malfunction. When your immune system tries to fight off an invading virus or bacterium, an abnormal immune response causes the immune system to attack the cells in the digestive tract. Heredity also seems to play a role in that ulcerative colitis is more common in people who have family members with the disease. However, most people with ulcerative colitis don’t have this family history.
Factors that may play a role in who develops UC include:
- Genes: You may inherit a gene from a parent that increases your chance.
- Other immune disorders: If you have one type of immune disorder, your chance for developing another one is higher.
- Environmental factors: Bacteria, viruses, and antigens may trigger the immune system.
Detailed clinical data and pathology annotations, biopsy, endoscopy data associated with the ulcerative colitis samples is provided to a valued customer for discovery, development and research.
Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens and human bio-fluid collections from cancer (tumor) tissue, cancer–serum, cancer–plasma cancer-PBMC and human tissue samples from most other therapeutic areas and diseases.
Bay Biosciences maintains and manages it’s own bio-repository, human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors available in all formats and types. Our biobank procures and stores fully consented, deidentified and institutional review boards (IRB) approved human tissue samples and matched controls.
All our human human tissue collections, human specimens and human bio-fluids are provided with detailed samples associated patient’s clinical data. This critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers and genetic information. Patient’s data is extremely valuable for researchers and is used to help identify new effective treatments (drug discovery & development) in oncology, other therapeutic areas and diseases. This clinical information is critical to demonstrate their impact, monitor the safety of medicines, testing & diagnostics, and generate new knowledge about the causes of disease and illness.
Bay Biosciences banks wide variety of human tissue samples and biological samples including cryogenically preserved -80°C, fresh, fresh frozen tissue samples, tumor tissue samples, FFPE’s, tissue slides, with matching human bio-fluids, whole blood and blood derived products such as serum, plasma and PBMC’s.
Bay Biosciences is a global leader in collecting and providing human tissue samples according to the researchers specified requirements and customized, tailor made collection protocols. Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.
Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors; including peripheral whole-blood, amniotic fluid, bronchoalveolar lavage fluid (BAL), sputum, pleural effusion, cerebrospinal fluid (CSF), serum (sera), plasma, peripheral blood mononuclear cells (PBMC’s), saliva, Buffy coat, urine, stool samples, aqueous humor, vitreous humor, kidney stones, renal calculi, nephrolithiasis, urolithiasis and other bodily fluids from most diseases including cancer. We can also procure most human bio-specimens and can do special collections and requests of human samples that are difficult to find. All our human tissue samples are procured through IRB approved clinical protocols and procedures.
In addition to the standard processing protocols Bay Biosciences can also provide human plasma, serum, PBMC bio-fluid samples using custom processing protocols, you can buy donor specific sample collections in higher volumes and specified sample aliquoting from us. Bay Biosciences also provides human samples from normal healthy donors, volunteers, for controls and clinical research, contact us Now.
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