Bay Biosciences provides high quality Wilms tumor also called Nephroblastoma tumor tissue samples FFPE blocks from unique pediatric patients for research, development and discovery.

Moreover, detailed clinical information associated with the samples are provided to a valued pharmaceutical customer for research.

Wilms Tumor Overview

A rare form of kidney cancer that primarily affects children is Wilms tumor. Specifically, known as nephroblastoma, it is the most common cancer of the kidneys in children.

In fact, each year, about 500 new cases of Wilms tumor are found in the United States, affecting about one in every 10,000 children. Moreover, Wilms tumor accounts for as many as 5% of cancers diagnosed each year.

Most importantly, it affects children between the ages of 3 and 4 years and becomes much less common in children after the age of 5 years. Furthermore, before the age of 10, nearly all cases of Wilms tumor are diagnosed, with two-thirds being found before the age of 10.

In addition, a family member with the disease (familial Wilms tumor) is present in about 1.5% of children with Wilms tumor. Additionally, tumors in both kidneys (called bilateral tumors), which may be inherited, are found in about 5 to 10% of children with Wilms tumor.

Signs and Symptoms of Wilms Tumor

Children with an average age of 3 to 4 years most often experience Wilms tumor. In addition, similar symptoms are associated with other childhood ailments, which makes having an accurate diagnosis essential. Specifically, the common signs and symptoms of Wilms tumor include:

Causes of Wilms Tumor

The exact causes of Wilms tumors are unknown. Moreover, so far, no clear links have been found between Wilms tumor and environmental factors. In particular, these factors include drugs, chemicals, or infectious agents, either during a mother’s pregnancy or after birth.

Genetic factors

On the other hand, regarding genetic factors, researchers do not believe that children directly inherit the condition from their parents. Specifically, only one to two percent of children with Wilms tumors have a relative who has had the same condition, and that relative typically is not a parent.

Nevertheless, certain genetic factors are believed by researchers to potentially increase a child’s risk or predispose children to developing Wilms tumor.

For instance, a child’s risk for Wilms tumor may be increased by the following genetic syndromes:

  • Beckwith-Wiedemann syndrome
  • WAGR syndrome
  • Denys-Drash syndrome
  • Frasier syndrome
  • Perlman syndrome
  • Sotos syndrome
  • Simpson-Golabi-Behmel syndrome
  • Bloom syndrome
  • Li-Fraumeni syndrome
  • Trisomy 18, also called Edward’s Syndrome.

Mutations

Changes or mutations in the WT1 gene are linked to Frasier syndrome, WAGR syndrome, and Denys-Drash syndrome. Additionally, a mutation in the WT2 gene is linked to Beckwith-Wiedemann syndrome, which causes body and organ enlargement. Both of these genes, found on chromosome 11, suppress tumors. However, only a small percentage of Wilms tumors can be accounted for by changes in these genes. Consequently, other gene mutations that remain undiscovered are likely present.

Furthermore, Wilms tumor may be more likely to occur in children with certain birth defects. Specifically, the condition is associated with the following birth defects:

  • Aniridia: a missing or partially missing iris
  • Hemihypertrophy: when one side of the body is larger than the other
  • Cryptorchidism: undescended testicles in boys
  • Hypospadias: Hypospadias forms a penis that not only doesn’t work well but also doesn’t look normal. The urinary opening is on the underside of the penis

Race

In terms of race, slightly more often does Wilms tumor occur in African-American children than in white children. Moreover, it is least common in Asian-American children.

Gender 

Regarding gender, the risk for the development of Wilms tumor may be higher in girls than boys.

Biospecimens

biospecimens

Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Human biospecimens are available including cancer (tumor) tissue, cancer serum, cancer plasma, cancer peripheral blood mononuclear cells (PBMC). and human tissue samples from most other therapeutic areas and diseases.

Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors for controls, available in all formats and types.

In fact, our biobank procures and stores fully consented, de-identified and institutional review boards (IRB) approved human tissue samples, human biofluids such as serum samples, plasma samples from various diseases and matched controls.

Also, all our human tissue collections, human biospecimens and human biofluids are provided with detailed, samples associated patient’s clinical data.

In fact, this critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Additionally, researchers find the patient’s data associated with the human biospecimens extremely valuable and use it to help identify new effective treatments (drug discovery & development) in oncology, as well as in other therapeutic areas and diseases.

Bay Biosciences banks wide variety of human tissue samples and human biological samples, including fresh frozen human biospecimens cryogenically preserved at – 80°C.

For example fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as human serum, human plasma and human PBMCs.

Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) and human biofluids from diseased and normal healthy donors which includes:

Moreover, we can also procure most human biospecimens and human biofluids, special collections and requests for human samples that are difficult to find. All our human tissue samples and human biofluids are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human biofluids such as  human plasma, human serum, and human PBMCs bio-fluid samples using custom processing protocols; you buy donor-specific collections in higher volumes and specified sample aliquots from us.

Bay Biosciences also provides human biospecimens from normal healthy donors; volunteers, for controls and clinical research, Contact us Now.