Bay Biosciences provides high quality, clinical grade cryopreserved (-80°C) human bronchoalveolar lavage fluid (BAL) cell pellets from untreated mild Asthma patients. Moreover, the BAL fluid samples were processed into cell pellets using customized processing protocols provided by the researcher.

Furthermore, the BAL fluid was centrifuged to yield the cell pellets, which were later suspended in freezing media (media + 10-20% FBS +10% DMSO). Moreover the bronchoalveolar lavage cell pellets were cryogenically preserved at, – 80 °C.

In addition, detailed clinical data, biomarker information, Spirometry, Peak flow, ENO, CT annotations and patients history associated with the mild asthma Bronchoalveolar lavage (BAL) cell pellet bio-specimens is provided to a valued customer for drug discovery, development and research.

Asthma Overview

Asthma is a chronic long-term inflammatory respiratory disease of the airways of the lungs. It makes breathing difficult and can make some physical activities challenging or even impossible. It causes the airways to get inflamed and narrow, making it difficult to breathe. Severe asthma or bronchial asthma can cause trouble talking or being active.

Normally when we breath the air goes through our nose. Consequently, to our mouth and down into our throat and into the airways, eventually making it to the lungs. 

There are many small air passages in the lungs that help deliver oxygen from the air into the bloodstream. Asthma symptoms occur when the lining of the airways swell and the muscles around them tighten. Mucus then fills the airways, further reducing the amount of air that can pass through. These conditions can then bring on an asthma “attack,” the coughing and tightness in the chest that’s typical of asthma.

Asthma Symptoms

There are three major signs of asthma:

  • Airway blockage: When you breathe as usual, the bands of muscle around your airways are relaxed, and air moves freely. But when you have asthma, the muscles tighten. It’s harder for the air to pass through.
  • Inflammation: Asthma causes red, swollen bronchial tubes in the lungs. This inflammation can damage the lungs.
  • Airway irritability: Patients with asthma have sensitive airways that tend to overreact and narrow when they come into contact with even slight triggers.

These problems may further cause the following symptoms:

  • Wheezing
  • Severe cough, especially at night and during exercise
  • Tightness, pain, pressure in the chest
  • Shortness of breath
  • Dizziness
  • Difficulty talking
  • Trouble sleeping because of breathing problems
  • Anxiousness or panic
  • Fatigue

Bronchoalveolar Lavage (BAL) Fluid

Bronchoalveolar lavage (BAL) fluid is also known as bronchoalveolar wash. In addition, bronchoalveolar lavage or BAL is a minimally invasive procedure that involves the installation of sterile normal saline into a subsegment of the lung, followed by suction and collection of the installed fluid for analysis.

Moreover, medical professionals use the bronchoalveolar lavage procedure for the diagnostics of diseases of the lower respiratory system. Specifically, healthcare providers use BAL sampling primarily to detect cytological abnormalities such as cancer, or to identify infectious pathogens.

During this procedure, a doctor passes a bronchoscope through the mouth or nose into an appropriate airway in the lungs, and an assistant introduces a measured amount of sterile saline fluid.

Subsequently, the medical staff wash the affected area with the fluid, and then they collect the same fluid back with a suction device and suction tubing for examination.

Respiratory Infections

In fact, the majority of pathological diseases occur within the lungs at the alveolar level. Specifically, bronchoalveolar lavage (BAL) allows for the collection of the alveolar milieu and further analysis of its composition. Moreover, bronchoalveolar lavage (BAL) is used for the diagnosis of opportunistic and atypical respiratory infections in immunocompromised patients, as well as unexplained radiographic pulmonary infiltrates or hypoxemia.

Furthermore, bronchoalveolar lavage (BAL) reveals specific information in disorders such as pulmonary alveolar proteinosis, Langerhans-cell histiocytosis, alveolar hemorrhage, malignant infiltration, hypersensitivity pneumonitis, pneumoconiosis. Additionally, other infiltrative processes, including sarcoidosis, asthma, chronic obstructive pulmonary disease (COPD), as well as exposure to dusts and chemicals, mesothelioma, along with the presence of malignant cells and asbestos exposure.

Purpose of BAL Samples

Bronchoalveolar lavage (BAL) is used for analyzing the lung parenchyma. Furthermore, cytology, Gram staining, and culturing can be performed on the fluids collected. In addition, biomarkers can be analyzed from BAL fluids, which can assist the researchers and doctors in establishing diagnosis, as well as in refining differential diagnosis, and in the clinical management of the patient while also providing insights for further research and development.

Moreover, as a research tool, Bronchoalveolar lavage (BAL) is used to characterize the effectiveness of intravenous drug delivery to the lungs and to improve understanding of lung biology in the distal lung. Specifically, it is able to collect inflammatory cells and mediators for analysis. Overall, Bronchoalveolar lavage (BAL) is invaluable to the understanding of disease states such as sarcoidosis and pulmonary fibrosis.

Biospecimens

biospecimens

Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Moreover, human biospecimens are available including tumor tissue, serum, plasma and PBMC samples from most other therapeutic areas.

Furthermore, Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and likewise normal healthy donors for controls. Additionally, available in all formats and types.

In fact, our biobank procures and stores fully consented, de-identified and institutional review boards (IRB) approved human tissue samples, human biofluids such as serum samples, plasma samples from various diseases and matched controls.

Also, all our human tissue collections, human biospecimens and human biofluids are provided with detailed, samples associated patient’s clinical data.

In fact, this critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Additionally, researchers find the patient’s data associated with the human biospecimens extremely valuable and use it to help identify new effective treatments (drug discovery & development) in oncology, as well as in other therapeutic areas and diseases.

Bay Biosciences banks wide variety of human tissue samples and human biological samples, including fresh frozen human biospecimens cryogenically preserved at – 80°C.

For example fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as human serum, human plasma and human PBMCs.

Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) and human biofluids from diseased and normal healthy donors which includes:

Moreover, we can also procure most human biospecimens and human biofluids, special collections and requests for human samples that are difficult to find. All our human tissue samples and human biofluids are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human biofluids such as  human plasma, human serum, and human PBMCs bio-fluid samples using custom processing protocols; you buy donor-specific collections in higher volumes and specified sample aliquots from us.

Bay Biosciences also provides human biospecimens from normal healthy donors; volunteers, for controls and clinical research, Contact us Now.