Bay Biosciences provides 2 ml fresh frozen bronchoalveolar lavage (BAL) fluid samples, processed into pellet and supernatant for research. The BAL samples are collected from unique patients diagnosed with Idiopathic pulmonary fibrosis (IPF) disease.

Moreover Detailed clinical data, serology, pathology annotations including patient’s biomarkers, corresponding diagnostic test values associated with the BAL samples are provided to a valued pharmaceutical customer for research.

 

Idiopathic Pulmonary Fibrosis (IPF) Overview

Idiopathic pulmonary fibrosis (IPF) is characterized by scarring (fibrosis) of the lungs due to an unknown reason. As time passes, the scarring worsens; consequently, this leads to shortness of breath and difficulty in taking deep breaths, resulting in insufficient oxygen intake.

In fact, IPF is a chronic lung disease. This signifies that it is a long-lasting disease that requires treatment. The term idiopathic pulmonary fibrosis provides some insight into the disease:

  • Idiopathic means the cause is not known.
  • Pulmonary means it affects the lung.
  • Fibrosis – the scarring caused by IPF is called fibrosis.

Moreover, IPF represents a form of interstitial lung disease that primarily impacts the interstitium (the tissue and space surrounding the air sacs of the lungs) without directly affecting the airways or blood vessels. In addition, numerous other types of interstitial lung disease can also induce inflammation and/or fibrosis; therefore, these are treated differently.

Signs and Symptoms of Idiopathic Pulmonary Fibrosis (IPF)

Following are the common signs and symptoms symptoms of Idiopathic Pulmonary Fibrosis (IPF) are:

The common signs and symptoms of Idiopathic Pulmonary Fibrosis (IPF) include:

  • Firstly, shortness of breath (also known as dyspnea or breathlessness): This symptom usually first appears during exercise. Furthermore, it can affect day-to-day activities such as showering, climbing stairs, getting dressed, and eating. As scarring in the lungs worsens, breathlessness may ultimately prevent all activities.
  • Secondly, chronic cough: Approximately 85% of individuals with Idiopathic Pulmonary Fibrosis (IPF) experience a chronic cough lasting longer than 8 weeks. Typically, this is often a dry cough; however, some may also cough up sputum.

Other symptoms may include:

Affects of Idiopathic Pulmonary Fibrosis on Lungs (IPF)

Airways, air sacs, and blood vessels are contained in the lung. Moreover, tissue exists in the small spaces between the air sacs and tiny blood vessels known as capillaries. Furthermore IPF disease causes this tissue to become inflamed, irritated, or swollen.

Consequently inflammation from idiopathic pulmonary fibrosis results in scarring over time. Therefore as the scarring worsens, the lungs become stiff. Moreover this stiffness makes it more difficult to take a deep breath. It also complicates the lung’s ability to send oxygen into the blood.

Causes of Idiopathic Pulmonary Fibrosis (IPF)

The cause of idiopathic pulmonary fibrosis (IPF) is unknown and not completely understood. In fact, “idiopathic” means of unknown cause. Moreover, common risk factors for IPF include:

  • First genetics (family history): Up to 20% of people with IPF have another family member with an interstitial lung disease. In addition, if more than one member of your family has IPF, the disease is called familial pulmonary fibrosis.
  • Additionally cigarette smoking: Approximately 75% of people with IPF are current or previous cigarette smokers.
  • Furthermore, acid reflux: Gastroesophageal reflux disease GERD. Approximately 75% of people with IPF have symptoms of acid reflux or heartburn.
  • Also, male sex: Approximately 75% of patients with IPF are male.
  • Finally, Age: Almost all patients with IPF are over the age of 50 years.

Biospecimens

biospecimens

Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Human biospecimens are available including cancer (tumor) tissue, cancer serum, cancer plasma, cancer peripheral blood mononuclear cells (PBMC). and human tissue samples from most other therapeutic areas and diseases.

Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors for controls, available in all formats and types.

In fact, our biobank procures and stores fully consented, de-identified and institutional review boards (IRB) approved human tissue samples, human biofluids such as serum samples, plasma samples from various diseases and matched controls.

Also, all our human tissue collections, human biospecimens and human biofluids are provided with detailed, samples associated patient’s clinical data.

In fact, this critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Additionally, researchers find the patient’s data associated with the human biospecimens extremely valuable and use it to help identify new effective treatments (drug discovery & development) in oncology, as well as in other therapeutic areas and diseases.

Bay Biosciences banks wide variety of human tissue samples and human biological samples, including fresh frozen human biospecimens cryogenically preserved at – 80°C.

For example fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as human serum, human plasma and human PBMCs.

Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) and human biofluids from diseased and normal healthy donors which includes:

Moreover, we can also procure most human biospecimens and human biofluids, special collections and requests for human samples that are difficult to find. All our human tissue samples and human biofluids are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human biofluids such as  human plasma, human serum, and human PBMCs bio-fluid samples using custom processing protocols; you buy donor-specific collections in higher volumes and specified sample aliquots from us.

Bay Biosciences also provides human biospecimens from normal healthy donors; volunteers, for controls and clinical research, Contact us Now.