Bay Biosciences provides high quality, clinical grade, biopsy tumor tissue samples, FFPE tumor tissue blocks with matched cryogenically preserved sera (serum), plasma, peripheral blood mononuclear cells (PBMC) biofluid samples from patients diagnosed with Burkitt’s lymphoma.
The sera (serum), plasma and PBMC biofluid specimens are processed from Burkitt’s lymphoma patient’s peripheral whole-blood using customized collection and processing protocols. The Burkitt’s lymphoma tumor tissue and matched biofluid samples are collected from unique patients diagnosed with Burkitt’s lymphoma and are provided to a valued pharmaceutical customer for research, diagnostics, discovery and drug development.
Detailed clinical data, patient’s history, symptoms, complete blood count (CBC), serology, MRI, biopsy tumor tissue findings, histopathology information, elevated biomarker levels, genetic and metabolic information associated with Burkitt’s lymphoma specimens is provided to a valued customer for research, development and drug discovery.
The Burkitt’s lymphoma sera (serum), plasma and peripheral blood mononuclear cells (PBMC) biofluids are processed from patients peripheral whole-blood using customized collection and processing protocols.
Burkitt’s Lymphoma Overview
Burkitt’s lymphoma is a type of non-Hodgkin’s lymphoma in which cancer starts in immune cells called B-cells. Burkitt’s lymphoma is a rare, fast growing and aggressive tumor, and is associated with impaired immunity. Non-Hodgkin’s lymphoma is a type of cancer of the lymphatic system, which helps your body fight infections.
Burkitt’s lymphoma is named after British surgeon Denis Burkitt, who identified this rare disease in 1956 among children in Africa. In Africa, Burkitt’s lymphoma is common in young children who also have malaria and Epstein-Barr, the virus that causes infectious mononucleosis. One reason may be that the malaria weakens the immune system’s response to Epstein-Barr, allowing it to change infected B-cells into cancerous cells. About 98% of African cases are associated with Epstein-Barr infection.
Burkitt’s lymphoma is also seen elsewhere, including the United States. Outside of Africa, Burkitt’s lymphoma is most likely to develop in patients who have a compromised immune system. Burkitt’s lymphoma is rare In the United States, about 1,200 patients are diagnosed each year, and majority of the patients are over the age of 40. Burkitt’s lymphoma is especially likely to develop in people infected with human immune virus (HIV), the virus that causes AIDS. Before highly active antiretroviral therapy (HAART) became a widespread treatment for HIV/AIDS the incidence of Burkitt’s lymphoma was estimated to be 1,000 times higher in HIV-positive people than in the general population.
Types of Burkitt’s Lymphoma
- Endemic (African): Endemic Burkitt lymphoma primarily affects African children ages 4 to 7 and is more commonly found in boys, two times more than the girls.
- Sporadic (non-African): Sporadic Burkitt’s lymphoma occurs all over the world. Globally, it accounts for 1 to 2 percent of adult lymphoma cases. In the United States and Western Europe, it accounts for up to 40 percent of pediatric lymphoma cases.
- Immunodeficiency-associated: This variant of Burkitt lymphoma is most common in people with HIV/AIDS. It accounts for 30 to 40 percentof non-Hodgkin lymphoma in HIV patients and may be an AIDS-defining disease. It can also occur in patients with congenital conditions that cause immune deficiency and in organ transplant patients who take immunosuppressive drugs.
Compared to the endemic type, the incidence of Epstein-Barr infection is considerably lower in the other two types of Burkitt’s lymphoma. In the sporadic disease, Epstein-Barr occurs in about 20% of the patients. With the immunodeficiency-associated type, it occurs in about 30 to 40 percent of patients. So, the association of Epstein-Barr virus with these two types of Burkitt’s lymphoma is unclear.
Signs and Symptoms of Burkitt’s Lymphoma
Burkitt’s lymphoma can cause fever, night sweats and unintentional weight loss. Other symptoms of Burkitt’s lymphoma vary according to the type of Burkitt’s Lymphoma.
Sporadic Burkitt’s lymphoma
Following are some of the common signs and symptoms of sporadic Burkitt’s lymphoma:
- Abdominal pain and swelling
- Facial Bones Distortion
- Intestinal Obstruction
- Night Sweats
- Enlarged Tonsils
- Enlarged Thyroid
- Enlarged Tonsils
Endemic Burkitt’s lymphoma
The symptoms of endemic Burkitt’s lymphoma include distortion of facial bones, swelling and a rapid growth of lymph nodes. The enlarged lymph nodes are non-tender. Tumors can grow very rapidll, sometimes doubling their size within 18 hours.
Immunodeficiency-related lymphoma
The symptoms of immunodeficiency-related lymphoma are similar to those of the sporadic type as described above.
Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens and human bio-fluid collections from cancer (tumor) tissue, cancer serum, cancer plasma cancer PBMC and human tissue samples from most other therapeutic areas and diseases.
Bay Biosciences maintains and manages it’s own bio-repository, human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors available in all formats and types. Our biobank procures and stores fully consented, deidentified and institutional review boards (IRB) approved human tissue samples and matched controls.
All our human human tissue collections, human specimens and human bio-fluids are provided with detailed samples associated patient’s clinical data. This critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers and genetic information. Patient’s data is extremely valuable for researchers and is used to help identify new effective treatments (drug discovery & development) in oncology, other therapeutic areas and diseases. This clinical information is critical to demonstrate their impact, monitor the safety of medicines, testing & diagnostics, and generate new knowledge about the causes of disease and illness.
Bay Biosciences banks wide variety of human tissue samples and biological samples including cryogenically preserved -80°C, fresh, fresh frozen tissue samples, tumor tissue samples, FFPE’s, tissue slides, with matching human bio-fluids, whole blood and blood derived products such as serum, plasma and PBMC’s.
Bay Biosciences is a global leader in collecting and providing human tissue samples according to the researchers specified requirements and customized, tailor made collection protocols. Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.
Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors; including peripheral whole-blood, amniotic fluid, bronchoalveolar lavage fluid (BAL), sputum, pleural effusion, cerebrospinal fluid (CSF), serum (sera), plasma, peripheral blood mononuclear cells (PBMC’s), saliva, Buffy coat, urine, stool samples, aqueous humor, vitreous humor, kidney stones, renal calculi, nephrolithiasis, urolithiasis and other bodily fluids from most diseases including cancer. We can also procure most human bio-specimens and can do special collections and requests of human samples that are difficult to find. All our human tissue samples are procured through IRB approved clinical protocols and procedures.
In addition to the standard processing protocols Bay Biosciences can also provide human plasma, serum, PBMC bio-fluid samples using custom processing protocols, you can buy donor specific sample collections in higher volumes and specified sample aliquoting from us. Bay Biosciences also provides human samples from normal healthy donors, volunteers, for controls and clinical research, contact us Now.
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