Causes of Infertility

Infertility Overview

Doctors generally define infertility as not conceiving after 12 months of regular sexual intercourse without birth control. Possible causes include a low sperm count in males and ovulation disorders in females.

Infertility is when a male or female cannot conceive due to a problem with the reproductive system of either partner.

Infertility can be primary or secondary. Primary infertility is when someone is not able to conceive at all. Secondary infertility is when someone has previously conceived but is no longer able to.

This article explains infertility’s causes, types, and treatment, as well as other things a person may wish to know about infertility in both sexes.

Causes of Infertility

Infertility is defined as the inability to get pregnant after 12 months of trying. Any person of either sex who fits this definition is experiencing infertility.

Causes in Males

The following are common causes of infertility in males:

Problems with semen and sperm

Semen is the milky fluid that the penis releases during ejaculation and consists of fluid and sperm. The fluid comes from the prostate gland, the seminal vesicle, and other sex glands. The sperm is produced in the testicles. When the ejaculate comes out of the penis, semen helps transport the sperm toward the egg.

Things that can make it more difficult for sperm to fertilize the egg include having a sperm count below 15 million, low pserm motility, or sperm that have an unusual shape and a harder time fertilizing the egg.

About 2% of males may have these types of issues with their sperm. They can result from:

• A medical condition: This could be a testicular infection, cancer, or a surgery.
• Overheated testicles: Causes include an undescended testicle, a varicocele, a varicose vein in the scrotum, the use of saunas or hot tubs, wearing tight clothes, and working in hot environments.
• Ejaculation disorders: If the ejaculatory ducts are blocked, semen may be ejaculated into the bladder.
• Hormonla imbalance: Hypogonadism, for example, can lead to a testosterone deficiency.

Other Causes in Men

Other causes may include:

• Genetic factors: A male should have an X and Y chromosome. If a person has two X chromosomes and one Y chromosome, as in Klinefelter syndrome, the testicles will develop abnormally, and there will be low testosterone and a low sperm count or no sperm.
• Mumps: If this occurs after puberty, inflammation of the testicles may affect sperm production.
• Hypospadias: With this congenital anomaly, the urethral opening is under the penis instead of at its tip. Doctors usually surgically correct this condition during infancy. If the correction is not done, it may be harder for the sperm to reach the female’s cervix. Hypospadias affects about 1 in every 200 newborn boys in the United States.
• Cystic fibrosis: This is a chronic disease that results in the creation of sticky mucus. This mucus mainly affects the lungs, but males may also have an absent vas deferens. The vas deferens carries sperm from the epididymis to the ejaculatory duct and the urethra.
• Radiation therapy or chemotherapy: These treatments can both impair sperm production. In the case of radiation therapy, the severity usually depends on how near to the testicles the radiation occurred.
• Other diseases: Conditions that are sometimes linked to lower fertility in males are anemia, Cushing’s syndrome, diabetes, and thyroid disease.
• Medications: Some medications increase the risk of fertility problems in males. These include sulfasalazine (Azulfidine) and anabolic steroids.

Causes in Females

Infertility in females can also have a range of causes.

Problems with Ovulation

Ovulation disorders make up about 25% of infertility cases in females. Ovulation is the monthly release of an egg. The eggs may never be released, or they may only be released in some cycles.

Ovulation disorders can occur due to:

• Hyperprolactinemia: If prolactin levels are high and the female is not pregnant or breastfeeding, it may affect ovulation and fertility.
• Thyroid problems: An overactive or underactive thyroid gland can lead to a hormonal imbalance that interferes with ovulation.
• Polycystic ovary syndrome (PCOS): This is a hormonal condition that can cause frequent or prolonged menstruation and can interfere with ovulation.

Problems in the uterus or fallopian tubes can also prevent the egg from traveling from the ovary to the uterus, or womb. If the egg does not travel, it can be harder to conceive naturally.

Other Causes in Females

Other causes include:

• Chronic conditions: These include AIDS or cancer.
• Primary ovarian insufficiency (POI): The ovaries stop working normally before the age of 40 years.
• Poor egg quality: The quality of the eggs may interfere with conception. As a female ages, the number and quality of the eggs declines. Eggs that are damaged or develop genetic abnormalities may also not be able to sustain a pregnancy. The older a female is, the higher the risk.
• Surgery: Pelvic surgery can sometimes cause scarring or damage to the fallopian tubes. Cervical surgery can sometimes cause scarring or shortening of the cervix. The cervix is the neck of the uterus.
• Submucosal fibroids: Benign or noncancerous tumors occur in the muscular wall of the uterus. They can interfere with implantation or block the fallopian tube, preventing sperm from fertilizing the egg.
• Endometriosis: Cells that normally occur within the lining of the uterus start growing elsewhere in the body.
• Tubal ligation: In females who have chosen to have their fallopian tubes blocked, the process can be reversed, but the chances of becoming fertile again are not high.

Risk Factors of Infertility

There are certain risk factors that can increase the chance of infertility for both sexes. These include:

• Age: The female’s ability to conceive may start to fall gradually before or around the age of 35 years, while male fertility starts to fall after the age of 40 years.
• Chemotherapy: Some chemotherapy drugs can result in ovarian failure or significantly reduce sperm count.
• Smoking: Smoking significantly increases the risk of infertility in both sexes, and it may undermine the effects of fertility treatment. Smoking during pregnancy increases the chance of pregnancy loss. Passive smoking has also been linked to lower fertility.
• Radiation: If this is aimed near the reproductive organs, it can increase the risk of fertility problems.
• Sexually transmitted infections (STIs): Chlamydia can damage the fallopian tubes in a female and cause inflammation in a male’s scrotum. Some other STIs may also cause infertility.

In addition, other factors may also be associated with infertility, though in many cases, the research is still insufficient. These include:

• Narcotics: Consumption of drugs such as cannabis or cocaine can lower the sperm count. Some females who use cannabis or cocaine may also have fertility problems.
• Exposure to certain chemicals: Some pesticides, herbicides, metals (such as lead), detergents, and solvents have been linked to fertility problems in both sexes.
• Obesity: This may reduce the chance of conceiving for both sexes.
• Stress: Stress can be a factor, especially if it leads to reduced sexual activity. It can also affect female ovulation and male sperm production.
• Exercise: Too much and too little exercise can lead to fertility problems in both sexes. In males, it can affect the sperm count.
• Nutrition: An unhealthy diet can impact fertility in males and females. If an eating disorder leads to serious weight loss, fertility problems may also arise.
• Alcohol abuse: Excessive alcohol consumption may reduce sperm count. It may also interfere with the success of in vitro fertilization (IVF) treatments.

Diagnosis of Infertility

An individual may want to visit a physician if there is no pregnancy after 12 months of trying.

If the female partner is over age 35 years, the couple may wish to see a doctor earlier, as fertility testing can take time. For example, a person over 35 years may want to see a doctor after 6 months, while a person over 40 years may want to see a doctor as soon as they realize they are not becoming pregnant.

A doctor can give advice and carry out some preliminary assessments.

The doctor may ask about a person’s sexual habits and make recommendations regarding these. Tests are available, but testing does not always reveal a specific cause.

Infertility Tests for Females

A female will undergo a general physical examination, and the doctor will ask about medical history, medications, menstruation cycle, and sexual habits.

They will also undergo a gynecologic examination and a number of tests:

• Blood test: This can assess hormone levels and whether a female is ovulating.
• Hysterosalpingography: A technician injects fluid into the uterus and takes X-rays to determine whether the fluid travels properly out of the uterus and into the fallopian tubes. If a blockage is present, surgery may be necessary.
• Laparoscopy: A thin, flexible tube with a camera at the end is inserted into the abdomen and pelvis, allowing a doctor to look at the fallopian tubes, uterus, and ovaries. This can reveal signs of endometriosis, scarring, blockages, and some irregularities in the uterus and fallopian tubes.

Other tests can include:

• ovarian reserve testing to count the eggs after ovulation
• pelvic ultrasound to produce an image of the uterus and ovaries
• thyroid function test, as this may affect the hormonal balance

Infertility Tests for Males

The doctor will ask about medical history, medications, and sexual habits and perform a physical examination.

If a test shows an abnormality, the doctor may recommend an examination of the testicles for lumps or deformities and an exam of the shape and structure of the penis.

In addition, the doctor may order the following tests:

• Semen Analysis: A sample may be taken to test for sperm concentration, motility, color, and quality, as well as the presence of blood or infection. Sperm counts can fluctuate, so several samples may be necessary.
• Blood test: The lab will test for levels of testosterone and other hormones.
• Ultrasound: This may reveal issues such as ejaculatory duct obstruction or retrograde ejaculation.
• Chlamydia test: Chlamydia can affect fertility, but antibiotics can treat it. However, antibiotics cannot cure any existing damage to fertility.

Treatment of Infertility

Treatment to help a person conceive naturally will depend on many factors, including the age of the person who wishes to conceive, how long infertility has lasted, personal preferences, and their general state of health.

If you and your partner have been trying to get pregnant and haven’t been able to, you may wish to seek treatment. The type of treatment that’s recommended can depend on a variety of factors, including:

• Age 
• How long you’ve been trying to conceive
• Overall health of both you and your partner
• Personal preferences of you and your partner, following consultation about your treatment options
• The cause of infertility, if known

Frequency of Intercourse

The first strategy a couple trying to conceive may wish to try is having sexual intercourse more often around the time of ovulation.

Typically the menstrual cycle lasts for about 28–32 days. Counting from the first day of the last period, a female will usually ovulate anywhere between day 11 and day 21.

Any person whose cycle is shorter than 21 days or longer than 35 days should see their doctor for an evaluation.

Treatment for Men

Male infertility can be treated in a variety of ways, depending on the cause. Treatment options for men can include surgery, medication, and assisted reproductive technology (ART).

Surgery can fix obstructions that are preventing sperm from being present in the ejaculate. It can also correct conditions such as varicocele. In some cases, sperm can be retrieved directly from the testicles after which it can be used in ART treatments.

Medications can be used to treat issues such as hormonal imbalances. They can also be used to treat other conditions that can affect male fertility, such as erectile dysfunction or infections that affect sperm count.

ART refers to treatments in which eggs and sperm are handled outside of the body. It can include treatments such as in vitro fertilization (IVF) and intracytoplasmic sperm injection. Sperm for ART treatments can be received from ejaculate, extraction from the testicles, or a donor.

Treatment for Women

The treatment for female infertility can also involve surgery, medication, and reproductive assistance such as ART. Sometimes several types of treatment are needed to help address female infertility.

Although surgery can sometimes be used to treat female infertility, it has become rarer now due to advancements in other fertility treatments. Surgery can improve fertility by:

• Correcting an abnormally shaped uterus
• Removing fibroids
• Unblocking fallopian tubes

Reproductive assistance can involve methods such as intrauterine insemination (IUI) and ART. During IUI, millions of sperm are injected into a woman’s uterus near the time of ovulation.

IVF is one type of ART and involves the removal of eggs that are then fertilized with a man’s sperm in a laboratory. After fertilization, the embryo is placed back into the uterus.

The medications used to treat female infertility work like hormones that are naturally present in the body to either encourage or regulate ovulation.

Other Treatments

However, timing intercourse may not be sufficient on its own to help a couple conceive. Treatments will depend on the underlying cause of infertility.

In males, this can include medications for erectile dysfunction. Surgery may include a procedure to remove a varicose vein in the scrotum or repair a blocked epididymis.

In females, doctors can prescribe fertility drugs to regulate or induce ovulation. These can include clomiphene (Clomid, Serophene), letrozole (Femara), dopamine agonist medications, and a variety of hormonal drugs.

If the fallopian tubes are blocked or scarred, surgical repair may make it easier for eggs to pass through. A person may also be advised to undergo IVF.

Doctors may also treat endometriosis with laparoscopic surgery. They make a small incision in the abdomen and insert a thin, flexible microscope with a light at the end, called a laparoscope. The surgeon can then remove implants and scar tissue, which may reduce pain and aid fertility.

Assisted Conception

The following methods are currently available for assisted or artificial conception:

• Intrauterine Insemination (IUI): At the time of ovulation, a doctor inserts a fine catheter through the cervix into the uterus to place a sperm sample directly into the uterus.
• In-vitro Fertilization (IVF): Doctors place the sperm with unfertilized eggs in a petri dish, where fertilization can take place. They then place the embryo in the uterus to begin a pregnancy. IVF techniques can include intracytoplasmic sperm injection (ICSI) and assisted hatching.
• Sperm or Egg Donation: If necessary, a person can use egg or sperm donation. Fertility treatment with donor eggs can be done using IVF.
• Electric or Vibratory Stimulation to Achieve Ejaculation: It may be possible to help a person achieve ejaculation with electric or vibratory stimulation. This can help a male who cannot ejaculate normally, for example because of a spinal cord injury.
• Surgical Sperm Aspiration: The sperm is removed from a part of the male reproductive tract such as the vas deferens, testicle, or epididymis. Doctors will use IVF to fertilize the egg or freeze the sperm for later use.

Infertility and Natural Treatments

Natural treatments can include methods such as acupuncture and yoga.

One 2018 review found that at least 29 percent of couples had tried some form of natural or alternative infertility treatment, either alone or to complement traditional treatments.

Acupuncture

Acupuncture involves the insertion of small, thin needles into various points of the body. It’s believed that these points can help stimulate the body’s energy flow.

There’s no definitive evidence to support acupuncture as a treatment for infertility.

A recent review of multiple clinical trials did find limited evidence that acupuncture could improve both ovulation and menstruation in women with PCOS. 

Yoga

Yoga incorporates postures and breathing techniques to promote relaxation and decrease stress levels.

Studies on yoga as an infertility treatment are limited. However, it’s believed that practicing yoga can be beneficial in relieving the stress that can be associated with undergoing fertility treatments.

Vitamins

Various vitamins and minerals can be beneficial in promoting fertility.

Some to look out for include:

• Folate
• Vitamin C
• Iron
• Vitamin E
• Zinc

You can also consider other supplements, such as probiotics, which can promote healthy digestion and improve overall wellness. 

Tea

A variety of fertility teas are commercially available for purchase.

Investigations into the effects of these tea formulations on fertility are extremely limited. However, one recent review found that antioxidant compounds found in green tea may help fertility by improving parameters such as sperm count and motility.

Essential Oils

Essential oils are derived from plants, typically from their roots, seeds, or leaves. They may be utilized in aromatherapy to promote relaxation and reduce stress levels. Aromatherapy can involve massaging with, bathing with, or burning essential oils.

Further research is needed to evaluate the effects that essential oils may have on fertility.

Fertility Diet

For women, fertility-boosting food recommendations are aimed at improving infertility caused by problems with ovulation. Therefore, they won’t work for infertility that’s caused by physical conditions such as a block in the fallopian tubes or uterine fibroids.

Some dietary recommendations for boosting fertility include:

• Avoiding trans fats, which are present in many fried and processed food products
• Choosing carbs wisely by focusing on fiber-rich foods (like vegetables  and whole grains) while avoiding refined carbs that are high in sugar
• Selecting high-fat dairy (like whole milk) instead of low-fat products
• Swapping some of your animal protein for vegetarian sources of protein

Following these recommendations, and eating a nutrient-rich diet in general, can also help men improve the health of their sperm.

Implementing dietary changes along with lifestyle changes such as being more active can help promote fertility.

Fertility Cycle

Women are most fertile around the time that they ovulate. Tracking your ovulation and then concentrating your sexual activity around this time can improve your chances of conceiving.

Ovulation occurs one day out of the month. At this time, your ovaries release a mature egg, which begins to travel through your fallopian tubes. If the egg encounters sperm during its journey, fertilization can occur.

If an egg isn’t fertilized, it will die within about 24 hours of ovulation. However, sperm can live within a women’s body for up to five days, increasing the chances of fertilization. Because of this, you’re actually fertile for around five to six days out of the month.

Ovulation doesn’t occur at the same time every month, so it’s important to recognize the signs of ovulation. These can include bodily changes such as abdominal cramping and a small rise in body temperature.

Infertility Facts and Statistics

According to the Centers for Disease Control and Prevention (CDC), 12.1 percent of U.S. women 15 to 44 years old have difficulty conceiving and carrying a child to term. Nearly 7 percent of married women in this age group are infertile.

Additionally, according to the CDC, 7.3 million women between ages 15 and 44 have used infertility services. That accounts for about 12 percent of women within that age group.

The National Institutes of Health (NIH) estimates that a woman in her 30s is half as fertile as a woman in her early 20s.

The Office on Women’s Health estimates that around 20 percent of women in the United States are now having their first child after age 35. This makes age a growing contributing factor toward infertility.

Around 9 percent of men have experienced issues with fertility. Although male fertility can also decline with increasing age, it declines more slowly than female fertility.

Infertility Outlook

Being diagnosed with infertility doesn’t mean that your dreams of having a child have come to an end. It may take some time, but a number of couples who experience infertility will eventually be able to have a child. Some will do so on their own, while others will need medical assistance.

For couples who experience fertility problems and those who wish to have children at an older age, there are more options available than ever before.

In 1978, the first baby was born as a result of IVF. Today, about 2.1% of all infants born in the United States annually are conceived via some form of assisted reproductive technology (ART).

Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Samples available include cancer (tumor) tissue, cancer serum, cancer plasma, cancer, peripheral blood mononuclear cells (PBMC). and human tissue samples from most other therapeutic areas and diseases.

Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors available in all formats and types.

Our biobank procures and stores fully consented, deidentified and institutional review boards (IRB) approved human tissue samples and matched controls.

All our human tissue collections, human specimens and human bio-fluids are provided with detailed, samples associated patient’s clinical data.

This critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Patient’s data is extremely valuable for researchers and is used to help identify new effective treatments (drug discovery & development) in oncology, and other therapeutic areas and diseases.

Bay Biosciences banks wide variety of human tissue samples and biological samples, including cryogenically preserved at – 80°C.

Including fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as serum, plasma and PBMC.

Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors which includes:

• Peripheral whole-blood
• Amniotic fluid
• Bronchoalveolar lavage fluid (BAL)
• Sputum
• Pleural effusion
• Cerebrospinal fluid (CSF)
• Serum (sera)
• Plasma
• Peripheral blood mononuclear cells (PBMC)
• Saliva
• Buffy coat
• Urine
• Stool samples
• Aqueous humor
• Vitreous humor
• Kidney stones (renal calculi)
• Other bodily fluids from most diseases including cancer.

We can also procure most human bio-specimens, special collections and requests for human samples that are difficult to find. All our human tissue samples are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human plasma, serum, and PBMC bio-fluid samples using custom processing protocols; you buy donor-specific collections in higher volumes and specified sample aliquots from us.

Bay Biosciences also provides human samples from normal healthy donors; volunteers, for controls and clinical research, contact us Now.

• 日本のお客様は、ベイバイオサイエンスジャパンBay Biosciences Japanまたはhttp://baybiosciences-jp.com/contact/までご連絡ください。