Bay Biosciences provides high quality, clinical grade, FFPE tissue blocks and matched cryogenically preserved sera (serum), plasma, peripheral blood mononuclear cells (PBMC) biofluid samples from patients diagnosed with celiac disease.
The sera (serum), plasma and PBMC biofluid specimens are processed from celiac disease patient’s peripheral whole-blood using customized collection and processing protocols. The celiac disease tissue and matched biofluid samples are collected from unique patients diagnosed with celiac disease and are provided to a valued pharmaceutical customer for research, diagnostics, discovery and drug development.
Detailed clinical data, celiac disease patient’s history, symptoms, complete blood count (CBC), serology, MRI, biopsy tissue, histopathology information, elevated biomarker levels, genetic and metabolic information associated with celiac disease specimens is provided to a valued customer for research, development and drug discovery.
The celiac disease sera (serum), plasma and peripheral blood mononuclear cells (PBMC) biofluids are processed from patients peripheral whole-blood using customized collection and processing protocols.
Celiac Disease Overview
Celiac disease is a digestive disease that damages the small intestine because of a sensitivity to gluten, which is found in wheat, rye, barley, and oats. This hereditary disorder interferes with the absorption of nutrients from food.
When patients with celiac disease eat foods containing gluten, their immune system responds by damaging the small intestine. Tiny fingerlike protrusions, called villi, which line the small intestine and enable the absorption of nutrients from food into the bloodstream, are lost. Without these villi, malnutrition occurs, regardless of how much food a person consumes.
Gluten
Gluten is a composite of gliadin and glutenin, two proteins found in grains such as wheat, barley and rye. These proteins help hold the grains together, providing the elasticity needed to make bread, pasta and other foods. Some people have difficulty digesting the proteins and find that consuming gluten causes digestive problems, such as bloating and irritable bowel, along with other unpleasant GIT symptoms.
Gluten in Foods
Gluten is found in most foods that are produced using wheat, barley or rye grain. It is not just found in bread and dough, gluten is also found in common foods like salad dressings, sauces, seasonings and beer. If you’re trying to eliminate gluten from your diet, you’ll need to read labels carefully, and remember to look for all the different ways gluten may be listed on the label. Many popular gluten-free foods are now clearly marked, which can help you find suitable alternatives. And you will easily find lots of information online about maintaining a gluten-free diet.
Gluten Allergy
When someone says they’re allergic to gluten, this usually means they have celiac disease. Celiac disease is an autoimmune disorder that causes damage to the small intestine when triggered by gluten consumption. Celiac disease patients will typically experience digestive problems along with other symptoms, like a skin rash or even seizures, when they eat foods containing gluten.
If you don’t have celiac disease but think your body may be sensitive to gluten, you can try eliminating gluten from your diet, then reintroducing it to see if symptoms subside or return. This can determine whether gluten is the cause in any symptoms you are experiencing.
Signs and Symptoms of Celiac Disease
Following are the common signs and symptoms of celiac disease:
- Chronic diarrhea or constipation
- Weight loss
- Recurring abdominal pain and bloating
- Gas
- Pale, foul-smelling stool
- Unexplained anemia
- Muscle cramps and/or bone pain
- Joint pain
- Tingling numbness in the legs
- Delayed growth
- Fatigue
- Painful skin rash
- Missed menstrual periods (which is linked to excessive weight loss)
- Tooth discoloration or loss of enamel
Causes of Celiac Disease
Patients genes combined with eating foods with gluten and other factors can contribute to developing celiac disease, but the precise cause isn’t known. Infant-feeding practices, gastrointestinal infections and gut bacteria might contribute, as well. Sometimes celiac disease becomes active after surgery, pregnancy, childbirth, viral infections or severe emotional stress. When the body’s immune system overreacts to gluten in food, the reaction damages the tiny, hair like projections (Villi) that line the small intestine. Villi absorb vitamins, minerals and other nutrients from the food you eat. If the villi are damaged, patients can’t get enough nutrients, no matter how much they eat.
Diagnosis of Celiac Disease
Once patients complete medical history and physical examination is done, the following diagnostic tests may be performed to diagnose celiac disease:
- Blood Tests: Blood works are performed to measure the level of antibodies to gluten. Researchers have found that persons with celiac disease have higher than normal levels of certain antibodies in their blood. These antibodies by the immune system in response to substances such as gluten, that the body perceives as threatening.
- Biopsy: To diagnose celiac disease, the doctor may remove a tiny piece of tissue from the small intestine to check for damage to the villi. During the procedure, the doctor eases a long, thin tube, called an endoscope, through the mouth and stomach into the small intestine. A sample of tissue is then taken using instruments passed through the endoscope. This procedure is considered the gold standard for diagnosis of celiac disease.
Treatment of Celiac Disease
Specific treatment for celiac disease will be determined by your doctor based on:
- Patient’s age, overall health, and medical history
- Extent of the disease
- Patient’s tolerance of specific medicines, procedures, or therapies
- Expectations for the course of the disease
- Patient’s opinion or preference
A gluten-free diet is the only treatment for persons with celiac disease. Adhering to a gluten-free diet is a lifetime requirement, as eating any gluten will further damage the intestine.
For most celiac disease patients, eliminating gluten from their diet will stop symptoms, heal intestinal damage that has already occurred, and prevent further damage. Usually, celiac disease patients will see an improvement in symptoms within days of starting the diet and, within three to six months, the small intestine is usually completely healed, with villi intact and working. For older patients, complete healing may take up to two years and to fully recover.
Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens and human bio-fluid collections from cancer (tumor) tissue, cancer serum, cancer plasma cancer PBMC and human tissue samples from most other therapeutic areas and diseases.
Bay Biosciences maintains and manages it’s own bio-repository, human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors available in all formats and types. Our biobank procures and stores fully consented, deidentified and institutional review boards (IRB) approved human tissue samples and matched controls.
All our human human tissue collections, human specimens and human bio-fluids are provided with detailed samples associated patient’s clinical data. This critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers and genetic information. Patient’s data is extremely valuable for researchers and is used to help identify new effective treatments (drug discovery & development) in oncology, other therapeutic areas and diseases. This clinical information is critical to demonstrate their impact, monitor the safety of medicines, testing & diagnostics, and generate new knowledge about the causes of disease and illness.
Bay Biosciences banks wide variety of human tissue samples and biological samples including cryogenically preserved -80°C, fresh, fresh frozen tissue samples, tumor tissue samples, FFPE’s, tissue slides, with matching human bio-fluids, whole blood and blood derived products such as serum, plasma and PBMC’s.
Bay Biosciences is a global leader in collecting and providing human tissue samples according to the researchers specified requirements and customized, tailor made collection protocols. Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.
Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors; including peripheral whole-blood, amniotic fluid, bronchoalveolar lavage fluid (BAL), sputum, pleural effusion, cerebrospinal fluid (CSF), serum (sera), plasma, peripheral blood mononuclear cells (PBMC’s), saliva, Buffy coat, urine, stool samples, aqueous humor, vitreous humor, kidney stones, renal calculi, nephrolithiasis, urolithiasis and other bodily fluids from most diseases including cancer. We can also procure most human bio-specimens and can do special collections and requests of human samples that are difficult to find. All our human tissue samples are procured through IRB approved clinical protocols and procedures.
In addition to the standard processing protocols Bay Biosciences can also provide human plasma, serum, PBMC bio-fluid samples using custom processing protocols, you can buy donor specific sample collections in higher volumes and specified sample aliquoting from us. Bay Biosciences also provides human samples from normal healthy donors, volunteers, for controls and clinical research, contact us Now.
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