Bay Biosciences provides high quality, clinical grade cryogenically preserved (-80°C) sera (serum), plasma, and peripheral blood mononuclear cells (PBMC) biofluid samples from patients diagnosed with systemic lupus erythematosus (SLE).

Furthermore, the sera (serum), plasma, and PBMC biofluid specimens are derived from patients’ peripheral whole blood. In addition, samples are processed using customized centrifugation protocols. Specifically tailored for unique systemic lupus erythematosus (SLE) patients for genomics, proteomics, and biomarker research.

Systemic Lupus Erythematosus (SLE) Overview

Moreover, SLE is an autoimmune and chronic inflammatory disease that causes multi-organ injury. Furthermore, including damage to the kidneys, blood, brain, and skin.

In fact, an autoimmune disease, is a condition in which the body’s immune system mistakenly attacks its own healthy tissue. Consequently, in many parts of the body, thereby causing widespread inflammation and tissue damage in the affected organs.

In general, the immune system normally guards against germs like bacteria and viruses. When it senses these foreign invaders, it consequently sends out an army of fighter cells to attack them. Normally, the immune system can, however, tell the difference between foreign cells and the body’s own cells.

On the other hand, in an autoimmune disease, the immune system mistakenly attacks parts of the body as foreign.  Moreover, parts such as the joints or skin. As a result, it releases proteins called autoantibodies that start attacking healthy cells.

Systemic Lupus Erythematosus (SLE) disease can affect the joints, skin, brain, heart, liver, lungs, kidneys, and blood vessels. Moreover, symptoms vary between people and may be mild to severe.

 

Symptoms

Common symptoms include rash, which is most commonly on the face, fever, chest pain, hair loss, painful and swollen joints, swollen lymph nodes, mouth ulcers, tiredness, and fatigue fatigue.

Additionally, features of SLE include periods of flare-up and remission, dysregulation of the immune system, and development of autoantibodies. At the more severe end of the spectrum, SLE can cause nephritis, neurological problems, anemia, and thrombocytopaenia (low level of platelets).

Consequently, SLE may be difficult to diagnose because its early signs and symptoms are not specific and can look like signs and symptoms of other diseases.

In order to assist in understanding the condition, detailed clinical data, biomarker information, Sm, RNP, PCNA, annotations, and patients’ history associated with the Systemic Lupus Erythematosus (SLE) sera & plasma specimens are provided to a valued customer for drug discovery, development, and research. Furthermore, SLE patients were matched by gender and age.

Additional Symptoms

  • Leukopenia, or low white blood cell count
  • Mouth ulcers
  • Painful or swollen joints
  • Skin problems, including rashes and tiny red spots
  • Sun sensitivity
  • vision problems
  •  Vomiting
  • Nausea
  • Weight loss

Complications

Between one-third and one-half of people living with lupus experience inflammation that affects their kidneys, resulting in a condition called lupus nephritis. Without treatment, lupus nephritis can progress to end-stage renal disease, which is a life-threatening condition.

Lupus nephritis causes the following symptoms:

  • Firstly, a butterfly-shaped rash on the face
  • Secondly, fever
  • Moreover, muscle aches
  • Finally, painful or swollen joints

Heart Complications

SLE can affect the heart, leading to inflamed tissue around this organ and abnormal heart valves, among other issues. Atherosclerosis, a form of heart disease, is more common among people with SLE than among those who do not have this condition.

SLE can damage the nervous system and contribute to the following conditions:

  • weakness in the limbs
  • changes in sensations
  • difficulty processing thoughts
  • Seizures

Causes of Systemic Lupus Erythematosus (SLE)

The exact cause of SLE remains unknown. However, variations or mutations in specific genes can increase a person’s risk of developing SLE.

The genetic mutations that researchers have associated with SLE often involve genes that regulate the body’s immune function, which are called major histocompatibility complex (MHC) genes.

However not everyone with an SLE gene variation will develop the condition.

Several other factors can increase the risk of someone developing SLE. Women are 10 times more likely to develop lupus than men, according to the American College of Rheumatology.

Other Causes

Other factors that can contribute to SLE include:

  • Diet
  • Exposure to toxic chemicals, sunlight, or certain medications
  • Sex hormones
  • Stress
  • Viral infections

Treatment of Systemic Lupus Erythematosus (SLE)

Currently, there is no cure for SLE. Treatments focus on reducing symptoms — or inducing remission — and preventing severe complications, such as end-stage renal disease.

Medication

Depending on the symptoms and the affected organs, a person with SLE may receive one or more of the following types of medication:

  • Antimalarials, including chloroquine (Aralen)
  • Blood thinners, such as warfarin (Coumadin)
  • Antimetabolites, such as methotrexate
  • Biologics, such as belimumab ( Benlysta)
  • Corticosteroids, for example, prednisone (Deltasone) creams
  • Immunosuppressive medications, which include azathioprine (Imuran) and cyclosporine (Neoral)
  • Nonsteroidal anti-inflammatory drugs (NSAIDs), which include aspirin

These medications work to reduce either inflammation, the activity of the immune system, or damage to the body resulting from SLE.

Dietary Changes

People who have SLE and lupus nephritis may wish to consider making the following dietary changes to help manage their symptoms:

  • Firstly, eating more plant-based proteins, such as nuts and beans
  • Secondly, limiting sodium intake
  • Moreover, eating potassium-rich foods, including bananas, potatoes, and whole-wheat bread
  • Furthermore, purchasing fresh food as often as possible
  • In addition, avoiding packaged food and premade meals
  • Also, eating smaller portions of animal proteins
  • Moreover, limiting saturated and trans fats
  • Finally, eating foods that are low in phosphorus, such as fresh fruits and vegetables

As people with SLE have an increased risk of heart disease, it is especially important to follow a healthful diet that reduces other risk factors, such as high blood pressure and obesity.

Biospecimens

biospecimens

Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Moreover, human biospecimens are available including tumor tissue, serum, plasma and PBMC samples from most other therapeutic areas.

Furthermore, Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and likewise normal healthy donors for controls. Additionally, available in all formats and types.

In fact, our biobank procures and stores fully consented, de-identified and institutional review boards (IRB) approved human tissue samples, human biofluids such as serum samples, plasma samples from various diseases and matched controls.

Also, all our human tissue collections, human biospecimens and human biofluids are provided with detailed, samples associated patient’s clinical data.

In fact, this critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Additionally, researchers find the patient’s data associated with the human biospecimens extremely valuable and use it to help identify new effective treatments (drug discovery & development) in oncology, as well as in other therapeutic areas and diseases.

Bay Biosciences banks wide variety of human tissue samples and human biological samples, including fresh frozen human biospecimens cryogenically preserved at – 80°C.

For example fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as human serum, human plasma and human PBMCs.

Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) and human biofluids from diseased and normal healthy donors which includes:

Moreover, we can also procure most human biospecimens and human biofluids, special collections and requests for human samples that are difficult to find. All our human tissue samples and human biofluids are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human biofluids such as  human plasma, human serum, and human PBMCs bio-fluid samples using custom processing protocols; you buy donor-specific collections in higher volumes and specified sample aliquots from us.

Bay Biosciences also provides human biospecimens from normal healthy donors; volunteers, for controls and clinical research, Contact us Now.