Metabolic Dysfunction-Associated Steatohepatitis (MASH) Samples for Research

Bay Biosciences provides liver biopsy FFPE tissue blocks with matched serum (sera), plasma, peripheral blood mononuclear cells (PBMC) biofluid samples and  from unique metabolic dysfunction-associated steatohepatitis (MASH) samples for research.

 

Metabolic Dysfunction-Associated Steatohepatitis (MASH) Overview

Excess fat cells in your liver cause metabolic dysfunction-associated steatohepatitis (MASH). In fact, doctors once called this condition nonalcoholic fatty liver disease (NASH).

Furthermore, chronic inflammation caused by excess fat cells can lead to worsening liver damage. Moreover, people often associate MASH with being overweight, having high blood lipids, and having high blood sugar.

What is Metabolic Dysfunction-Associated Steatohepatitis (MASH)?

Metabolic dysfunction-associated steatohepatitis (MASH) is a serious liver disease that develops when fat buildup in your liver causes inflammation.

In fact, doctors previously called this condition nonalcoholic steatohepatitis (NASH). Furthermore, without treatment, MASH can lead to conditions like cirrhosis and liver cancer.

Moreover, MASH is part of a broader group of liver diseases that researchers call MASLD (metabolic dysfunction-associated steatotic liver disease).

Additionally, conditions like obesity, Type 2 diabetes, and high cholesterol increase your risk of developing MASH. Therefore, if you have these conditions, you should ask your healthcare provider if you should have tests that may show signs of MASH.

Symptoms of Metabolic Dysfunction-Associated Steatohepatitis (MASH)

You may not show symptoms of MASH until it severely damages your liver. In fact, the condition develops slowly over the years.

Furthermore, when you do experience symptoms, they may include:

– Fatigue
-Discomfort or pain in your upper right belly
– Muscle weakness or muscle loss
– Swollen belly or legs
– Yellowish tint to your eyes and skin (jaundice) as the condition worsens.
–Unexplained weight loss

Moreover, because early MASH often shows no obvious symptoms, it’s important for you to get regular checkups, especially if you have risk factors like obesity, diabetes, or high cholesterol.

Causes of Metabolic Dysfunction-Associated Steatohepatitis (MASH)

MASH occurs when the liver accumulates too much fat and triggers inflammation. In addition, health issues with how your body processes sugar and fat often link to this condition.

Common causes and risk factors, therefore, include:

– Obesity or overweight
– 
– High cholesterol
-Type 2 diabetes
– High triglycerides
– Obesity or over weight
– High blood pressure
– Insulin resistance

Furthermore, you may develop MASH even if you don’t have overweight but experience issues such as high cholesterol or high blood pressure.

Diagnosis of Metabolic Dysfunction-Associated Steatohepatitis (MASH)

Diagnosing MASH involves several steps because it doesn’t cause symptoms right away. First, a healthcare provider performs a physical exam.

Additionally, they ask if you have any conditions that increase your risk of developing MASH. Furthermore, they conduct blood tests and imaging tests. In some cases, they may perform a liver biopsy.

Blood Tests

Specifically, your provider conducts blood tests to look for damage or inflammation in your liver. These tests may include:

– CBC
– BMP
– Lipid panel
– Hemoglobin A1C

Imaging Tests

Moreover, these tests provide images of your liver’s inside. Consequently, your provider looks for changes in your liver that could be signs of MASH. Imaging tests may include:

– CT scan
– Ultrasound
– FibroScan, a type of liver elastography
– Magnetic resonance elastography and proton density fat fraction (MRE-PDFF), which measures fat in your liver

Moreover, your provider may perform a liver biopsy to get a small sample of your liver. Subsequently, a medical pathologist cuts the sample into tiny pieces. Then, they examine the sample under a microscope for signs of fat, inflammation, and scarring. Ultimately, a liver biopsy is the most accurate way to diagnose MASH.

Finally, your provider may conduct other tests to rule out other liver diseases that can cause your symptoms.

Treatment of Metabolic Dysfunction-Associated Steatohepatitis (MASH)

MASH treatment focuses on improving your metabolic health and protecting your liver from further damage. In addition, your treatment plan may include lifestyle changes, medication, or bariatric surgery.

Firstly, Lifestyle changes: You can manage MASH by losing weight through healthy eating and becoming more active. Specifically, suggested lifestyle changes may include:

For instance, eating well. You can follow good food plans for managing MASH, such as the Mediterranean diet or low-carb diet. Moreover, being active. You should build up to 150 to 300 minutes of moderate-intensity aerobic exercise per week. Furthermore, avoiding alcohol. Even a small amount of alcohol can put stress on your liver.

Next, Medication: Your provider can prescribe medications that reduce MASH symptoms like scarring. For example, examples are:

One option is Resmetiron (Rezdiffra). This drug can slow down or reverse the scarring in your liver that MASH can cause.

Notably, it’s the only drug with U.S. Food and Drug Administration (FDA) approval to treat MASH with fibrosis stages 2 and 3. Additionally, GLP-1 agonists.

These drugs can reduce inflammation and fat in your liver. Examples include liraglutide (Victoza, Saxenda), semaglutide (Ozempic, Wegovy), and tirzepatide (Mounjaro, Zepbound).

Moreover, your provider may prescribe other medications or supplements. For instance, they might prescribe pioglitazone (Actoplus Met XR), which treats diabetes. Alternatively, they might recommend a supplement like vitamin E.

Researchers study new medications for MASH in clinical trials. Consequently, ask your provider if joining a trial might be a good option for you.

Bariatric Surgery

Furthermore, bariatric surgery can be a treatment option if you have obesity and advanced liver disease. Specifically, surgeries like gastric sleeve surgery or gastric bypass surgery can:

– Help you lose weight
– Improve or even reverse liver damage from MASH
– Dramatically reduce your risk of liver cirrhosis, liver cancer, and needing a liver transplant.

Complications of Metabolic Dysfunction-Associated Steatohepatitis (MASH)

Without treatment, MASH can lead to serious and potentially life-threatening complications, including:

First, liver fibrosis. Specifically, scarring in your liver worsens over time and leads to cirrhosis.

Then, cirrhosis. Consequently, severe scarring affects how your liver works.

Moreover, this is often permanent. Additionally, liver failure. **In fact**, liver failure may occur suddenly, so you need immediate medical treatment or a liver transplant.

Furthermore, hepatocellular carcinoma. As a result, MASH raises your risk of this common liver cancer.\

Lastly, heart disease. Ultimately, the condition increases your risk of heart attack, stroke, and other conditions that affect your heart.

Outlook of Metabolic Dysfunction-Associated Steatohepatitis (MASH)

Is MASH Curable?

MASH isn’t always curable. However, early diagnosis and treatment may reverse the condition or keep it from getting worse.

Your life expectancy depends on how much damage MASH does to your liver. Specifically, when caught early, many people live a normal lifespan with treatment.

On the other hand, in more advanced stages, the risk of complications like liver failure, liver cancer, or early death increases, but treatment can still slow the disease and improve your quality of life.

Therefore, starting care as soon as possible gives you the best chance for a better outcome.

Biospecimens

Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Samples available include cancer (tumor) tissue, cancer serum, cancer plasma, cancer, peripheral blood mononuclear cells (PBMC). and human tissue samples from most other therapeutic areas and diseases.

Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors available in all formats and types.

In fact, our biobank procures and stores fully consented, de-identified and institutional review boards (IRB) approved human tissue samples and matched controls.

Also, all our human tissue collections, human specimens and human bio-fluids are provided with detailed, samples associated patient’s clinical data.

So this critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Additionally, patient’s data is extremely valuable for researchers and is used to help identify new effective treatments (drug discovery & development) in oncology, and other therapeutic areas and diseases.

Bay Biosciences banks wide variety of human tissue samples and biological samples, including cryogenically preserved at – 80°C.

For example fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as serum, plasma and PBMC.

Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors which includes:

Moreover, we can also procure most human bio-specimens, special collections and requests for human samples that are difficult to find. All our human tissue samples are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human plasma, serum, and PBMC bio-fluid samples using custom processing protocols; you buy donor-specific collections in higher volumes and specified sample aliquots from us.

Bay Biosciences also provides human samples from normal healthy donors; volunteers, for controls and clinical research, contact us Now.

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