Bay Biosciences provides high quality, clinical grade bio-samples, muscle biopsy tissue, sera (serum), plasma and peripheral blood mononuclear cells (PBMC) from patients diagnosed with Polymyositis disease.

Moreover, the serum, plasma and PBMCs are processed from patient’s peripheral whole-blood using customized processing protocols.

Furthermore the samples are collected from patients diagnosed with polymyositis disease and provided to a valued pharmaceutical customer for research, development and drug discovery.

Detailed clinical data, elevated biomarker levels, serology, biomarkers, Jo-1, MDA5, TIF1γ, Mi2, PL-7, PL-12, KS, EJ, genetic information, muscle biopsy tissue, pathology annotations, associated with the Polymyositis patient’s specimens is provided to a valued customer for drug discovery, development and research. The Polymyositis disease PBMC, sera (serum) and plasma samples were processed from patients peripheral whole blood using customized processing protocols provided by the researcher. Bay Biosciences specializes in providing researchers with high quality, clinical grade customized human samples, bio-specimens and human bio-fluid collections worldwide.

Polymyositis Overview

Polymyositis is a rare inflammatory disease (inflammatory myopathy) that causes muscle weakness and pain affecting both sides of the body. Specifically, it inflames the muscles and their related tissues, like the blood vessels that supply them.

Furthermore, the inflammation of polymyositis is mainly found in the endomysial layer (within the muscle) of the skeletal muscle. Whereas, dermatomyositis is characterized primarily by inflammation of the perimysial layer of skeletal muscle.

Moreover, polymyositis is an autoimmune disease, which means that the body’s immune system attacks its own tissue, consequently causing the related problems. In addition, polymyositis is more common in patients with other autoimmune conditions, such as lupus and rheumatoid arthritis.

Similarly, it is also more common among HIV patients. Furthermore, polymyositis and the associated inflammatory myopathies have an associated increased risk of developing tumors and cancer.

Causes of Polymyositis

Polymyositis is a rare condition. Specifically, it typically affects people between the ages of 31 and 60 years, and moreover, it is more common among women than men.

The exact cause of polymyositis is unclear. Nevertheless, the condition shares many similarities with autoimmune diseases.

In an autoimmune disease, the immune system mistakenly attacks healthy tissue in the body. In particular, in people with polymyositis, the immune system may attack muscle fibers, causing damage and inflammation.

Additionally, some genes may also influence the risk of polymyositis.

Risk Factors

Risk factors for polymyositis include:

  • First, lupus
  • Second, rheumatoid arthritis
  • Moreover, scleroderma
  • Furthermore, Sjogren’s Syndrome
  • In addition, viral infections like HIV and AIDS
  • Lastly, pulmonary diseases that affect patient’s ability to breathe

Symptoms of Polymyositis

The symptoms of polymyositis are caused by inflammation in the muscles. Furthermore, the muscle weakness affects both sides of the body equally. In addition, the condition tends to target the muscle groups that are closest to the trunk of the body, including the hips, shoulders, thighs, upper arms, upper back, and neck.

Consequently, patients affected by polymyositis have trouble lifting their arms over their heads, walking up flights of stairs, rising from a chair, or carrying things. Although in some cases, it may be hard to swallow food, this is unusual.

Moreover, the patient may not have pain in the areas where the muscles are weak. Over time, the muscles may atrophy, meaning they waste away or become less bulky.

Typically, the condition often worsens slowly, and the patients might not notice symptoms for months. In fact, muscle weakness may be one of the first symptoms polymyositis patients notice, and they may also feel that they just can’t do all the things they used to.

Additionally, polymyositis patients may also have:

  • Fever
  • Fatigue
  • Joint pain
  • Raynaud’s Syndrome, a condition in which the fingers or toes become very cold and discolored due to problems with blood flow.
  • Weight loss

Diagnosis of Polymyositis

To diagnose polymyositis, a doctor will perform a physical examination and assess a person’s medical history. If the doctor suspects polymyositis, they may order one or more of the following tests:

Blood Tests

Firstly, blood tests. A person who has polymyositis may have high levels of antibodies specific to muscle inflammation or creatine kinase (CK) in the blood.

In fact, antibodies are proteins that the immune system releases as part of the inflammatory process. As a result, high levels of antibodies can, therefore, indicate the presence of underlying inflammatory diseases, such as polymyositis.

Furthermore, CK is an enzyme present in muscle fibers. Consequently, when muscle fibers become damaged, CK leaks out of the fibers and into the bloodstream.

Electromyography Test

An electromyography (EMG) test assesses the function of muscles and the nerves that control them.

Firstly, the test involves inserting a fine needle called an electrode into the muscle. Subsequently, a doctor will then ask the person to contract the muscle. Moreover, a computer monitor records the electrical activity of the muscle in response to the contraction.

Imaging Tests

In addition, imaging tests, such as MRI or ultrasound scans, can help a doctor identify muscle inflammation.

Muscle Biopsy

Furthermore, a muscle biopsy involves removing a small amount of muscle tissue for closer examination.

Treatment of Polymyositis

Although there is no cure for polymyositis, nevertheless, treatments are available to help manage the inflammation and alleviate symptoms.

Specifically, some potential treatment options include:

  • Corticosteroids and anti-inflammatory medications to reduce muscle inflammation
  • Immunosuppressant drugs to suppress the immune system and control inflammation
  • Intravenous immunoglobulin, which uses healthy antibodies to counteract the antibodies that are damaging the muscles
  • Physical therapy to help strengthen the muscles and improve mobility
  • Speech therapy to treat associated speech difficulties and disorders.

Biospecimens

biospecimens

Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Moreover, human biospecimens are available including tumor tissue, serum, plasma and PBMC samples from most other therapeutic areas.

Furthermore, Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and likewise normal healthy donors for controls. Additionally, available in all formats and types.

In fact, our biobank procures and stores fully consented, de-identified and institutional review boards (IRB) approved human tissue samples, human biofluids such as serum samples, plasma samples from various diseases and matched controls.

Also, all our human tissue collections, human biospecimens and human biofluids are provided with detailed, samples associated patient’s clinical data.

In fact, this critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Additionally, researchers find the patient’s data associated with the human biospecimens extremely valuable and use it to help identify new effective treatments (drug discovery & development) in oncology, as well as in other therapeutic areas and diseases.

Bay Biosciences banks wide variety of human tissue samples and human biological samples, including fresh frozen human biospecimens cryogenically preserved at – 80°C.

For example fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as human serum, human plasma and human PBMCs.

Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) and human biofluids from diseased and normal healthy donors which includes:

Moreover, we can also procure most human biospecimens and human biofluids, special collections and requests for human samples that are difficult to find. All our human tissue samples and human biofluids are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human biofluids such as  human plasma, human serum, and human PBMCs bio-fluid samples using custom processing protocols; you buy donor-specific collections in higher volumes and specified sample aliquots from us.

Bay Biosciences also provides human biospecimens from normal healthy donors; volunteers, for controls and clinical research, Contact us Now.