Bay Biosciences provides high quality, clinical grade, lung squamous cell carcinoma (SCC) fresh frozen tumor tissue samples, FFPE tumor tissue blocks, normal adjacent tissue bio-specimens, and matched cryogenically preserved sera (serum), plasma, peripheral blood mononuclear cells (PBMC) and bronchoalveolar lavage fluid (BAL) biofluid samples from patients diagnosed with squamous cell carcinoma (SCC) of the lung.

Moreover, the serum, plasma and PBMCs are processed from non-small cell lung carcinoma (NSCLC), subtype squamous cell carcinoma (SCC) patient’s peripheral whole-blood using customized collection and processing protocols.

Furthermore, the biopsy tumor tissue, normal adjacent tissue and matched biofluid samples are collected from unique patients diagnosed with stage III and IV NSCLC-SCC and are provided to a valued pharmaceutical customer for research, diagnostics, discovery and drug development.

In addition, detailed clinical information associated with squamous cell carcinoma specimens is provided to a valued customer for research, development and drug discovery.

 

Squamous Cell Carcinoma (SCC) of the Lung Overview

Squamous cell carcinoma (SCC) of the lung, also known as epidermoid carcinoma, is a form of lung cancer. Specifically, there are two main types of lung cancers: small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC).

In fact, squamous cell carcinoma is a subtype of non-small cell carcinoma. Moreover, squamous cell carcinoma (SCC) is the most common type of lung cancer in men, and it’s more common in men than in women. Furthermore, smoking tobacco mostly causes it.

Interestingly, squamous cell carcinoma is named after squamous cells, which are types of cells that are flat and thin and look like fish scales. Consequently, many different parts of the body contain them. As a result, a squamous cell carcinoma can develop anywhere in the body where squamous cells are located.

Typically, squamous cell carcinoma usually begins in the bronchi (the passages that bring air into the lung) and grows more slowly than other main forms of lung cancer, which include adenocarcinoma and small cell lung cancer.

  • On the other hand, adenocarcinoma begins along the outer edges of the lungs and under the lining of the bronchi in secretory (glandular) cells. Ultimately, it is the most common type of lung cancer in patients who have never smoked.”
     
  • Small-cell lung cancer grows rapidly and quickly spreads to other organs.

Following are the four main types of squamous cell carcinomas (SCC) of the lung:

  • Papillary Carcinoma
  • Small cell Carcinoma
  • Clear cell Carcinoma
  • Basaloid Carcinoma

Usually basaloid and certain small-cell types of cancer may have a worse prognosis than other types of squamous cell carcinoma.

Signs and Symptoms of Squamous Cell Carcinoma (SCC) of the Lung

Signs and symptoms of squamous cell carcinoma are similar to signs and symptoms of other types of lung cancer. In general, lung cancer does not usually cause symptoms at first. However, symptoms usually begin after cancer has spread (metastasized). Furthermore, symptoms may vary from patient to patient.

For instance, the following are some of the most common signs and symptoms of lung cancer:

Additionally, squamous cell carcinoma of the lung can also have symptoms similar to other cancers in general, such as:

  • Fatigue (extreme tiredness)
  • Loss of appetite
  • Unexplained weight loss
  • Headache
  • Pain all over the body
  • Broken or fractured bones

Risk Factors of Squamous Cell Carcinoma (SCC) of the Lung

Squamous cell carcinoma (SCC) of the lung is strongly related to patients history of tobacco smoking. SCC’s more closely associate with tobacco smoking than other forms of lung cancer.

Following are several common factors that increases the risk of developing squamous cell carcinoma (SCC):

Diagnosis of Squamous Cell Carcinoma (SCC) of the Lung

Following diagnostics tests are performed for the diagnosis of squamous cell carcinoma (SCC):

  • CT scans: CT scans show lesions that may not be detected on an x-ray
  • X-rays: X-rays can show a tumor in the lungs
  • Sputum cytology: In this test, the doctor uses mucus from coughing to see if there are cancerous cells
  • Bronchoscopy: In this test, the doctor examines the lungs using a lighted tube that’s passed down the throat and into the lungs
  • Mediastinoscopy: In this test a doctor may make an incision in the neck and surgically remove a tissue samples from lymph nodes
  • Needle biopsy: In this test a doctor will inserts a needle through the chest wall and into the lungs to take cell samples for evaluation
  • Biopsy: A small tumor tissue sample, a lymph nodes or other areas are taken for examination to see where the cancer could have spread

TesResults

After the test results are available, your doctor will carefully analyze your imaging test results and tissue samples findings to assess if you have squamous cell carcinoma or another form of lung cancer. Most patients with early stage squamous cell carcinoma don’t usually have  signs and symptoms, and the cancerous cells can’t be seen on an x-ray. It tends to spread outside the chest area more slowly (and later) than other major types of lung cancer. When doctors examine a biopsy, tumor’s from squamous cell carcinoma can range from well-differentiated to showing only minimal squamous cell features.

Once doctors find out what kind of lung cancer you have, they will try to find out how advanced your cancer is and at what stage it’s at, and whether it’s spread beyond the lungs. Moreover, the stages of lung cancer range from stage 0 to stage IV, with the lower stages indicating cancer that is limited to the lung and stage IV. Consequently, indicating the cancer has spread to other parts of the body.Knowing the stage will help your doctor determine the right treatment options.

Following additional tests are performed to determine the stage of the cancer:

  • CT scans 
  • MRI
  • Positron emission tomography (PET), which is an imaging test that shows how your organs and tissues are functioning using a radioactive drug 
  • Bone scans 

Treatment of Squamous Cell Carcinoma (SCC) of the Lung

Treatment plans for lung cancer depends on the type of lung cancer you have, the stage of the lung cancer, and your overall health and preferences. You may receive one type of treatment or a combination of multiple types of treatment. The most common treatments for lung cancer are surgery, chemotherapy and radiation therapy.

Surgery

Lung cancer surgery involves removing cancer from your lungs, your doctor may decide surgery is right for you.  

Following are the three types of surgery commonly used to treat lung cancer:

  • Segmentectomy or wedge resection, in which a surgeon surgically removes a small part of the lung.
  • Lobectomy, in which a surgeon surgically removes one or two lobes of the lung.
  • Pneumonectomy, in which a surgeon surgically removes an entire lung.

Radiation Therapy

Radiation therapy sends high-energy beams of radiation to shrink cancer cells and destroy tumors. Additionally, it may be used in combination with surgery or chemotherapy. Specifically, there are two types of radiation therapy; sometimes, both types are used to treat lung cancer.

Chemotherapy

In contrast, chemotherapy treatments are drugs that can kill cancer. Moreover, chemotherapy drugs stop cancerous cells from being able to grow and reproduce. Consequently, chemotherapy may be used alone or along with radiation therapy or surgery.

Other Lung CancerTreatments

Furthermore, following are some of the other treatments used for lung cancer patients:

  • Photodynamic therapy (PDT), otherwise known as laser therapy, which is a type of cancer treatment that targets cancerous cells
  • Targeted therapies are medications that block blood vessels in new tumors to stop them from growing

Biospecimens

biospecimens

Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Moreover, human biospecimens are available including tumor tissue, serum, plasma and PBMC samples from most other therapeutic areas.

Furthermore, Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and likewise normal healthy donors for controls. Additionally, available in all formats and types.

In fact, our biobank procures and stores fully consented, de-identified and institutional review boards (IRB) approved human tissue samples, human biofluids such as serum samples, plasma samples from various diseases and matched controls.

Also, all our human tissue collections, human biospecimens and human biofluids are provided with detailed, samples associated patient’s clinical data.

In fact, this critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Additionally, researchers find the patient’s data associated with the human biospecimens extremely valuable and use it to help identify new effective treatments (drug discovery & development) in oncology, as well as in other therapeutic areas and diseases.

Bay Biosciences banks wide variety of human tissue samples and human biological samples, including fresh frozen human biospecimens cryogenically preserved at – 80°C.

For example fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as human serum, human plasma and human PBMCs.

Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) and human biofluids from diseased and normal healthy donors which includes:

Moreover, we can also procure most human biospecimens and human biofluids, special collections and requests for human samples that are difficult to find. All our human tissue samples and human biofluids are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human biofluids such as  human plasma, human serum, and human PBMCs bio-fluid samples using custom processing protocols; you buy donor-specific collections in higher volumes and specified sample aliquots from us.

Bay Biosciences also provides human biospecimens from normal healthy donors; volunteers, for controls and clinical research, Contact us Now.