Unexplained Weight Loss Overview

Unexplained weight loss is, in fact, a significant reduction in body weight that occurs unintentionally; notably, weight loss occurs even if the person is not trying to lose weight. Furthermore, unexplained weight loss can be a symptom of a serious disease or health conditions, including cancer or diabetes. Therefore, it is important to seek medical attention if a person experiences weight loss that cannot be explained.

Clinical Definition of Unexplained Weight Loss

In addition, unexplained weight loss is a noticeable drop in body weight that occurs even if the person is not intentionally trying to lose weight. Importantly, the weight loss does not happen because of a special diet, exercise, or lifestyle changes. Specifically, weight loss of 10 pounds or more, or five percent of body weight, over a period of 6 to 12 months is considered unexplained.

Risk Factors of Unexplained Weight Loss

Moreover, unexplained weight loss can happen to anyone. However, it is most common and more serious in older people over the age of 65. Notably, unexplained weight loss of less than five percent of body weight or 10 pounds may be the sign of a serious health condition or disease in older people.

Causes of Unexplained Weight Loss

Finally, following are some of the health conditions and diseases that can cause unexplained weight loss. Consequently, these conditions could be related to diseases that range from mild to very serious conditions.

In addition, these causes can be physical or psychological:

  • Addison’s disease
  • AIDS
  • Alcohol or drug abuse
  • Anxiety
  • Cancer
  • Celiac Disease (gluten intolerance)
  • Crohn’s disease (an inflammation of the bowels)
  • Dental problems
  • Dementia
  • Depression
  • Diabetes 
  • Drug abuse
  • Dysphagia (swallowing problems)
  • Heart failure
  • Parkinson’s disease 
  • Gastrointestinal problems, such as ulcerative colitis or peptic ulcers
  • Dental problems
  • Swelling of pancreas
  • Side effects of prescription medications
  • An overactive or underactive thyroid gland
  • A parasitic infection
  • Undiagnosed eating disorders

Biospecimens

biospecimens

Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens, and human bio-fluid collections.

Moreover, human biospecimens are available including tumor tissue, serum, plasma and PBMC Samples from most other therapeutic areas.

Furthermore, Bay Biosciences maintains and manages its own biorepository, the human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and likewise normal healthy donors for controls. Additionally, available in all formats and types.

In fact, our biobank procures and stores fully consented, de-identified and institutional review boards (IRB) approved human tissue samples, human biofluids such as serum samples, plasma samples from various diseases and matched controls.

Also, all our human tissue collections, human biospecimens and human biofluids are provided with detailed, samples associated patient’s clinical data.

In fact, this critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers, and genetic information.

Additionally, researchers find the patient’s data associated with the human biospecimens extremely valuable and use it to help identify new effective treatments (drug discovery & development) in oncology, as well as in other therapeutic areas and diseases.

Bay Biosciences banks wide variety of human tissue samples and human biological samples, including fresh frozen human biospecimens cryogenically preserved at – 80°C.

For example fresh frozen tissue samples, tumor tissue samples, formalin-fixed paraffin-embedded (FFPE), tissue slides, with matching human bio-fluids, whole blood and blood-derived products such as human serum, human plasma and human PBMCs.

Bay Biosciences is a global leader in collecting and providing human tissue samples according to the specified requirements and customized, tailor-made collection protocols.

Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.

Types of Biospecimens

Bay Biosciences provides human tissue samples (human specimens) and human bio-fluids from diseased and normal healthy donors which includes:

  • Firstly, peripheral whole-blood
  • Secondly, amniotic fluid
  • Thirdly, bronchoalveolar lavage fluid (BAL)
  • Next, sputum
  • Also, pleural effusion
  • Moreover, cerebrospinal fluid (CSF)
  • Likewise, serum (sera)
  • In addition, plasma
  • Moreover, peripheral blood mononuclear cells (PBMC) 
  • Furthermore, saliva
  • Next, buffy coat
  • Accordingly, urine
  • And, Stool samples
  • Also, aqueous humor
  • Additionally, vitreous humor
  • Lastly, kidney stones (renal calculi)
  • Finally, other bodily fluids from most diseases including cancer.

Moreover, we can also procure most human biospecimens and human biofluids, special collections and requests for human samples that are difficult to find. All our human tissue samples and human biofluids are procured through IRB-approved clinical protocols and procedures.

In addition to the standard processing protocols, Bay Biosciences can also provide human biofluids such as  human plasma, human serum, and human PBMCs bio-fluid samples using custom processing protocols. you buy donor-specific collections in higher volumes and specified sample aliquots from us in multiple format and sets.

Bay Biosciences also provides human biospecimens from normal healthy donors; volunteers, for controls and clinical research, Contact us Now.