Causes of High Cholesterol Levels

Causes of High Cholesterol Overview

High cholesterol, also known as hypercholesterolemia, refers to high levels of either LDL or total cholesterol in the body.

It can occur if a person eats a diet high in fat. Other causes of high cholesterol include genetic disorders, such as familial hypercholesterolemia, stress, a sedentary lifestyle, medications, and some health conditions.

What is Cholesterol?

Cholesterol is present in every cell of the body. The body produces cholesterol, but people also consume it in food. It is an oil-based substance and does not mix with blood, which is water-based.

It has four primary functions:

• Allowing the body to produce vitamin D
• Contributing to the structure of cell walls
• Enabling the body to make certain hormones
• Making up digestive bile acids in the intestine

Cholesterol travels around the body in lipoproteins. Two types of lipoprotein carry the parcels of cholesterol:

• Low-density lipoprotein (LDL): Cholesterol that travels in this way is unhealthful or “bad” cholesterol.
• High-density lipoprotein (HDL): HDL is known as “good” cholesterol.

It is also important to take into account triglycerides and total cholesterol:

• Triglycerides: This is a type of fat the body uses for energy. High triglyceride levels combined with high LDL (bad) cholesterol or low HDL (good) cholesterol can increase the risk of heart attack and stroke.
• Total cholesterol: The complete amount of LDL cholesterol, HDL cholesterol, and triglyceride levels in the blood.

Causes of High Cholesterol

Cholesterol in the body mostly comes from the liver. However, every cell in the body can also produce it.

Several factors can lead to increased LDL levels. Some of these include:

Genetic features

Some people have high cholesterol levels due to their genes. Familial hypercholesterolemia is an inherited disease, and people with this condition have increased blood levels of LDL cholesterol.

Dietary factors

High cholesterol can result from a diet high in fat. Reducing the intake of fat in the diet helps manage cholesterol levels. In particular, it is helpful to limit foods that contain:

• Cholesterol: This is present in animal foods, meat, and cheese.
• Saturated fat: This occurs in some meats, dairy products, chocolate, baked goods, and deep-fried and processed foods.
• Trans fats: This occurs in some fried and processed foods.

Learn more about high cholesterol foods..

Stress

Stress may contribute to high cholesterol levels.

For instance, an older 2013 study found a link between high levels of work stress and high levels of LDL and total cholesterol.

However, more research is necessary to verify the link between stress and high cholesterol levels.

Sedentary lifestyle

A sedentary lifestyle may contribute to high cholesterol levels.

A 2015 study found evidence that people with a moderate weigh who spend more time sitting and using a screen may have higher bad LDL and total cholesterol levels, while those who spend more time in physical activity have higher good cholesterol or HDL levels.

Medications

People who take certain drugs may have higher total and LDL cholesterol levels and lower HDL levels.

Commonly known medications that have a negative effect on lipid levels include:

• Antipsychotics
• Cardiovascular medications
• Anticonvulsants
• Hormones
• certain immunosuppressives
• SGLT2 inhibitors to treat diabetes
• Progestins anabolic steroids and corticosteroids

Health conditions

Some health conditions increase the chance of developing high cholesterol. These include:

• Diabetes
• High blood pressure
• Obesity
• Liver or kidney disease
• Nephrotic syndrome
  
• Polycystic ovary syndrome
• Pregnancy and other conditions that increase levels of female hormones
• Under active thyroid gland

Risk Factors of High Cholesterol

Having certain risk factors can increase the chance of having high cholesterol. These include:

• Age, 45 years and over for males and 55 years and over for females
• Excess weight or obesity
• Smoking

Levels and Ranges of Cholesterol

Preventing High Cholesterol

Knowing the causes of high cholesterol can help a person reduce or manage their cholestrol levels, including:

• Avoiding smoking
• Eating a heart-healthy diet 
• Exercising regularly
• Achieving and maintaining a moderate weight

Since 2018, new guidelines urged doctors to discuss with individuals the following factors that may increase risk:

• Family history and ethnicity
• Certain health conditions that increase the risk of high cholesterol, such as chronic kidney disease (CKD)
  or chronic inflammatory conditions

Taking these factors into consideration will lead to a more personalized approach to the treatment and prevention of high cholesterol levels.

Frequently Asked Questions (FAQs)

Below are some commonly asked questions on the causes of high cholesterol.

What foods will cause high cholesterol?

Following a nutritious, balanced diet is one way to help with moderate cholesterol levels. According to the American Heart Association, a person may wish to avoid foods containing saturated fats. Examples include red meat, sausages, bacon, and organ meats such as kidney and liver.

Does stress increase cholesterol?

Stress may increase cholesterol levels. This can happen indirectly through adopting less healthy habits as a coping method. There may also be a direct biological link. However, more research is necessary on this topic.

Can alcohol cause high cholesterol?

Alcohol does not contain cholesterol. However, a high alcohol intake of over 30 grams (g) per day may have a negative effect on lipid or cholesterol profiles. Researchers are still investigating the link between the two.

A standard drink is any beverage containing 14 g of pure alcohol. Therefore, two standard drinks per day contain around 28 g.

What is the normal cholesterol level by age?

Cholesterol levels typically increase with age. A healthy total cholesterol level for a person under the age of 19 years is less than 170mg/dL, while for people aged 20 years or older it is 125–200 mg/dL.

A person’s doctor can provide them with more information about what their cholesterol level should ideally be based on their age and other factors.

How do you reduce cholesterol in your body?

To reduce or manage cholesterol in the body, a person can get enough physical exercise and achieve and maintain a moderate weight. They can also choose foods that are lower in trans fats and highly processed foods.

What reduces cholesterol quickly?

A doctor may prescribe medication alongside lifestyle changes to help reduce cholesterol more quickly. Examples of high cholesterol medications include statins, bile acid sequestrants, niacin, fibrates, and injectable PCSK9 inhibitors.

Summary

Cholesterol is an essential substance that the body produces but which people also consume in foods such as meat, dairy, and poultry products.

Some people have a family history of high cholesterol, and genetic factors may play a role.

Eating a heart-healthy diet and exercising regularly are some lifestyle choices people can make to manage their cholesterol levels.

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