Bay Biosciences provides high quality, clinical grade, biopsy tumor tissue samples, FFPE tumor tissue blocks with matched cryogenically preserved sera (serum), plasma, peripheral blood mononuclear cells (PBMC) biofluid samples from patients diagnosed with diffuse large B-cell lymphoma.
The sera (serum), plasma and PBMC biofluid specimens are processed from diffuse large B-cell lymphoma patient’s peripheral whole-blood using customized collection and processing protocols. The diffuse large B-cell lymphoma tumor tissue and matched biofluid samples are collected from unique patients diagnosed with diffuse large B-cell lymphoma and are provided to a valued pharmaceutical customer for research, diagnostics, discovery and drug development.
Detailed clinical data, patient’s history, symptoms, complete blood count (CBC), serology, MRI, biopsy tumor tissue findings, histopathology information, elevated biomarker levels, genetic and metabolic information associated with diffuse large B-cell lymphoma specimens is provided to a valued customer for research, development and drug discovery.
The diffuse large B-cell lymphoma sera (serum), plasma and peripheral blood mononuclear cells (PBMC) biofluids are processed from patients peripheral whole-blood using customized collection and processing protocols.
Diffuse Large B-Cell Lymphoma Overview
Diffuse large B-cell lymphoma (DLBCL) is a cancer that starts in white blood cells called lymphocytes. It usually grows in lymph nodes, which are the pea-sized glands located in the neck, groin, armpits, and elsewhere in the body, that are part of the immune system. Lymphocytes are part of the immune system, they travel around the body in the lymphatic system, helping fight infections. There are two types of lymphocytes: T lymphocytes or T-cells and B lymphocytes or B cells. Diffuse large B-cell lymphoma (DLBCL) can also develop in other areas of your body.
Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin’s lymphoma (NHL) in the United States and worldwide, accounting for about 22 percent of newly diagnosed cases of B-cell NHL in the United States. More than 18,000 patients are diagnosed with diffuse large B-cell lymphoma (DLBCL) each year.
Diffuse large B-cell lymphoma (DLBCL) is an aggressive, fast-growing non-Hodgkin’s lymphoma (NHL) that affects B-lymphocytes. Lymphocytes are one type of white blood cell. B-cells are lymphocytes that make antibodies to fight infections and are an important part of the lymphatic system. Diffuse large B-cell lymphoma (DLBCL) can occur in childhood, the occurrence of DLBCL generally increases with age, and most patients are diagnosed over the age of 60.
Diffuse large B-cell lymphoma (DLBCL) can develop in the lymph nodes or in “extranodal sites” which are areas outside the lymph nodes, such as the gastrointestinal tract, testes, thyroid, skin, breast, bone, brain, or essentially any organ of the body. It may be localized, in one spot or generalized spread throughout the body.
Types of Diffuse Large B-Cell Lymphoma
Most patients with diffuse large B-cell lymphoma (DLBCL) do not have a specific type. This is known as Diffuse large B-cell lymphoma (DLBCL) not otherwise specified or ‘DLBCL NOS’. Around 25% to 30% of non-Hodgkin’s lymphoma (NHL) cases diagnosed in adults in developed countries are DLBCL-NOS, and this percentage is even higher in developing countries. Usually diffuse large B-cell lymphoma (DLBCL) patients biopsy tissue sample is analyzed to find out the exact type of B cell the lymphoma developed from. There are other ways of categorizing cases of DLBCL-NOS into molecular subgroups based on their genetic and immunophenotypic characteristics.
Following are the main cell types:
- Germinal Center B Cells (GCB)
- Activated B Cells (ABC)
Currently most patients with diffuse large B-cell lymphoma (DLBCL) not otherwise specified (NOS) have the same treatment. However, researchers are working to find out if different treatments that maybe more effective against specific types of diffuse large B-cell lymphoma (DLBCL) that developed from different cells. In future, this may help doctors choose the more effective and appropriate treatment for each type of diffuse large B-cell lymphoma (DLBCL).
Sub-Types of Diffuse Large B-Cell Lymphoma
Some patients have a rare subtype of diffuse large B-cell lymphoma (DLBCL) or other large B-cell lymphoma. These subtypes are usually detected by looking at the biopsy tissue sample under a microscope or using specialist laboratory tests. These sub-types of DLBCL can cause different symptoms from the most common type of DLBCL NOS.
Following are other and rare type of diffuse large B-cell lymphoma (DLBCL):
- Primary mediastinal large B-cell lymphoma (PMBL)
- T-cell/histocyte-rich B-cell lymphoma
- Epstein-Barr (Virus) EBV-positive DLBCL Not otherwise specified (NOS)
- ALK-positive large B-cell lymphoma
- Intravascular large B-cell lymphoma
Primary mediastinal large B-Cell Lymphoma (PMBL)
Primary mediastinal large B-cell lymphoma (PMBL) was previously classified as a subtype of diffuse large B-cell lymphoma (DLBCL) but now it is considered as a separate type of lymphoma. Usually it affects patients in their 20’s and 30’s and is more common in women patients than men.
Primary mediastinal large B-cell lymphoma (PMBL) usually develops from B cells in the thymus gland, which is a small gland in located in the chest, behind the breastbone. PMBL tends to grow as a large lump inside the chest where it cannot be seen or felt. It can spread to the lymph nodes but usually it doesn’t spread to other parts of the body.
PMBL can cause symptoms by pressing on the lungs, esophagus or the large vein that carries blood from the body to the heart, the superior vena cava or SVC. It can also cause fluids to build up around the heart known as pericardial effusion or pleural effusion in the lungs. Symptoms might include:
- Shortness of breath
- Dizziness
- Headache
- Cough
- Swelling around the face and neck
- Difficulty swallowing food
T-cell/histiocyte-rich large B-cell lymphoma
T-cell/histiocyte-rich large B-cell lymphoma gets its name from the cells pathologists can see when they look at a biopsy tissue sample under a microscope. It can develop at any age but it most commonly affects middle-aged men.
Following are the common signs and symptoms of T-cell/histiocyte-rich large B-cell lymphoma :
- Swollen lymph nodes
- Swelling of the liver or spleen, which can cause abdominal swelling and discomfort
- General feeling of being unwell, with B symptoms
- Fever
- Night sweats
- Unexplained weight loss
Epstein-Barr (Virus) EBV-positive DLBCL Not Otherwise Specified (NOS)
Epstein-Barr (Virus) EBV-positive diffuse large B-cell lymphoma (DLBCL) Not Otherwise Specified (NOS) subtype of DLBCL typically develops in people over 50, but it can also affect younger people. It is linked to a virus called Epstein–Barr virus (EBV), which infects B cells. Most patients have been infected with EBV but it doesn’t usually cause any symptoms. Only a very small number of people who have had EBV develop lymphoma.
Symptoms of EBV-positive diffuse large B-cell lymphoma (DLBCL) depend on where the lymphoma develops:
- Most patients (7 in 10) have lymphoma growing outside their lymph nodes (extranodal lymphoma), most commonly in the skin, lungs, tonsils or stomach. The patients symptoms depend on where in your body the lymphoma is growing.
- Some patients (3 in 10) have lymphoma only in their lymph nodes.
ALK-positive large B-cell Lymphoma
This is a very rare subtype of diffuse large B-cell lymphoma (DLBCL) that can affect patients of any age. It is more common in men than women. The lymphoma cells have a mutation that means they make a protein called ‘anaplastic large-cell kinase’ (ALK). Unlike other types of diffuse large B-cell lymphoma (DLBCL), they don’t usually make a protein called CD20. Most patients with this subtype of lymphoma have enlarged lymph nodes but the lymphoma can also grow in the chest or other parts of the body.
Intravascular large B-cell lymphoma
Intravascular large B-cell lymphoma mainly affects older patients. The abnormal lymphocytes are found within small blood vessels known as capillaries. This subtype of lymphoma doesn’t usually cause enlarged lymph nodes. The exact symptoms depend on which capillaries are affected, but might include the following:
- Nervous system symptoms such as confusion, seizures, dizziness or weakness
- Red patches or lumps on the skin
- B symptoms (fever, night sweats, unexplained weight loss)
- Enlarged spleen
- Enlarged liver
Bay Biosciences is a global leader in providing researchers with high quality, clinical grade, fully characterized human tissue samples, bio-specimens and human bio-fluid collections from cancer (tumor) tissue, cancer serum, cancer plasma cancer PBMC and human tissue samples from most other therapeutic areas and diseases.
Bay Biosciences maintains and manages it’s own bio-repository, human tissue bank (biobank) consisting of thousands of diseased samples (specimens) and from normal healthy donors available in all formats and types. Our biobank procures and stores fully consented, deidentified and institutional review boards (IRB) approved human tissue samples and matched controls.
All our human human tissue collections, human specimens and human bio-fluids are provided with detailed samples associated patient’s clinical data. This critical patient’s clinical data includes information relating to their past and current disease, treatment history, lifestyle choices, biomarkers and genetic information. Patient’s data is extremely valuable for researchers and is used to help identify new effective treatments (drug discovery & development) in oncology, other therapeutic areas and diseases. This clinical information is critical to demonstrate their impact, monitor the safety of medicines, testing & diagnostics, and generate new knowledge about the causes of disease and illness.
Bay Biosciences banks wide variety of human tissue samples and biological samples including cryogenically preserved -80°C, fresh, fresh frozen tissue samples, tumor tissue samples, FFPE’s, tissue slides, with matching human bio-fluids, whole blood and blood derived products such as serum, plasma and PBMC’s.
Bay Biosciences is a global leader in collecting and providing human tissue samples according to the researchers specified requirements and customized, tailor made collection protocols. Please contact us anytime to discuss your special research projects and customized human tissue sample requirements.
Bay Biosciences provides human tissue samples (human specimens) from diseased and normal healthy donors; including peripheral whole-blood, amniotic fluid, bronchoalveolar lavage fluid (BAL), sputum, pleural effusion, cerebrospinal fluid (CSF), serum (sera), plasma, peripheral blood mononuclear cells (PBMC’s), saliva, Buffy coat, urine, stool samples, aqueous humor, vitreous humor, kidney stones, renal calculi, nephrolithiasis, urolithiasis and other bodily fluids from most diseases including cancer. We can also procure most human bio-specimens and can do special collections and requests of human samples that are difficult to find. All our human tissue samples are procured through IRB approved clinical protocols and procedures.
In addition to the standard processing protocols Bay Biosciences can also provide human plasma, serum, PBMC bio-fluid samples using custom processing protocols, you can buy donor specific sample collections in higher volumes and specified sample aliquoting from us. Bay Biosciences also provides human samples from normal healthy donors, volunteers, for controls and clinical research, contact us Now.
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